Total Synthesis, of TAK-Kinase Inhibitor LL-Z1640-2 via Consecutive Macrocyclization and Transannular Aromatization

被引：34

作者：

Miyatake-Ondozabal, Hideki ^{[1
]}

Barrett, Anthony G. M. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 23期

基金：

英国工程与自然科学研究理事会;

关键词：

RESORCYLIC ACID LACTONES; CONVERGENT SYNTHESIS; BIOMIMETIC SYNTHESIS; NATURAL-PRODUCTS; HYPOTHEMYCIN; MACROLIDES; EFFICIENT;

D O I：

10.1021/ol102468k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The biomimetic total synthesis of LL-Z1640-2 (3) is reported without the use of phenol protection. The aromatic unit was constructed via the transannular aromatization of macrocyclic triketo-ester 2, which in turn was synthesized by macrolactonization using an intramolecular trapping of a triketo-ketene derived from dioxinone 1.

引用

页码：5573 / 5575

页数：3

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