The effect of ovarian reserve and receptor signalling on granulosa cell apoptosis during human follicle development

被引：37
作者：
Regan, Sheena L. P. [1 ]
Knight, Phil G. [2 ]
Yovich, John L. [3 ]
Stanger, James D. [3 ]
Leung, Yee [4 ]
Arfuso, Frank [1 ]
Almahbobi, Ghanim [5 ]
Dharmarajan, Arun [1 ]
机构：
[1] Curtin Univ, Stem Cell & Canc Biol Lab, Sch Biomed Sci, Curtin Hlth Innovat Res Inst, GPO Box U1987, Perth, WA 6845, Australia
[2] Univ Reading, Sch Biol Sci, Hopkins Bldg, Reading RG6 6UB, Berks, England
[3] PIVET Med Ctr, Perth, WA, Australia
[4] King Edward Mem Hosp Women, Western Australian Gynaecol Canc Serv, Perth, WA, Australia
[5] Curtin Univ, Sch Biomed Sci, Curtin Hlth Innovat Res Inst, Perth, WA, Australia
来源：
MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2018年 / 470卷
关键词：
Ageing; Granulosa cell; Receptor expression; Fertility; Apoptosis; IN-VITRO FERTILIZATION; STIMULATING-HORMONE RECEPTOR; BOVINE ANTRAL FOLLICLES; LUTEINIZING-HORMONE; GONADOTROPIN STIMULATION; ALTERNATIVE PATHWAYS; MEMBRANA GRANULOSA; REPRODUCTIVE AGE; OVULATION RATE; ESTROUS-CYCLE;
D O I：
10.1016/j.mce.2017.11.002
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The poor oocyte quality in older women has previously been linked to the depletion of the ovarian reserve of primordial follicles and an increase in granulosal apoptosis. Granulosa cells were collected from 198 follicles and individually analysed by flow cytometry. In the young IVF patients, the level of apoptosis was inversely proportional to the expression of bone morphogenetic protein (BMPRIB) and follicle stimulating hormone (FSH) receptors. Conversely, in the older patients this relationship became dysregulated. In the older patients, at the time of preovulatory maturation, the reduced apoptosis reflects the poor mitogenic growth turnover rate of healthy follicles rather than the death rate in an atretic follicle. Restoring an optimum receptor density and down-regulation of receptors may improve oocyte quality and the pregnancy rate in older women. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：219 / 227
页数：9
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