Broad spectrum identification of SUMO substrates in melanoma cells

被引：27

作者：

Ganesan, Anand K.

Kho, Yoonjung

Kim, Sung Chan

Chen, Yue

Zhao, Yingming

White, Michael A.

机构：

[1] Univ Calif Irvine, Dept Dermatol, Irvine, CA 92697 USA

[2] Univ Texas, SW Med Ctr Dallas, Dept Biochem, Dallas, TX 75235 USA

[3] Univ Texas, SW Med Ctr Dallas, Dept Cell Biol, Dallas, TX 75235 USA

来源：

PROTEOMICS | 2007年 / 7卷 / 13期

关键词：

BRAF; melanoma; signal transcluction; SUMO;

D O I：

10.1002/pmic.200600971

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Like phosphorylation, protein sumoylation likely represents a dynamic PTM to alter protein function in support of cell regulatory systems. The broad-spectrum impact of transient or chronic engagement of signal transduction cascades on protein sumoylation has not been explored. Here, we find that epidermal growth factor (EGF) stimulation evokes a rapid alteration in small ubiquitin modifier (SUMO) target selection, while oncogene expression alters steady-state SUMO-protein profiles. A proteomic SUMO target analysis in melanoma cells identified proteins involved in cellular signaling, growth control, and neural differentiation.

引用

收藏

页码：2216 / 2221

页数：6

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