Prognostic value of oxygen saturation and heart rate during a six-minute walk test in pediatric pulmonary hypertension

被引：0

作者：

Atasayan, Vildan ^{[1
]}

CanbeylI, Fatma ^{[2
]}

Tunaoglu, Fatma Sedef ^{[3
]}

Oguz, Ayse Deniz ^{[3
]}

CelIk, Bulent ^{[4
]}

Kula, Serdar ^{[1
]}

机构：

[1] Umraniye Educ & Res Hosp, Dept Pediat Cardiol, Istanbul, Turkey

[2] Kirikkale Univ, Fac Med, Dept Pediat Cardiol, Kirikkale, Turkey

[3] Gazi Univ, Fac Med, Dept Pediat Cardiol, Ankara, Turkey

[4] Gazi Univ, Fac Sci, Dept Stat, Ankara, Turkey

来源：

TURKISH JOURNAL OF MEDICAL SCIENCES | 2021年 / 51卷 / 04期

关键词：

6-minute walk test; pulmonary arterial hypertension; survival; heart rate; ARTERIAL-HYPERTENSION; RATE RECOVERY; CHILDREN; GUIDELINES; MANAGEMENT; SURVIVAL; INSIGHTS; DISTANCE; BOSENTAN; REGISTRY;

D O I：

10.3906/sag-2004-220

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background/aim: Th evaluate the pre and post-treatment heart rate and oxygen (O-2) saturation values measured before, during and after 6MWT in children who received PAH-specific treatment and to determine the effect of these variables on prognosis. Materials and methods: This retrospective study included 29 patients who were diagnosed as PAH and treated. The transcutaneous O-2 saturation and heart rate levels were recorded before the test: baseline (Sat0, HR0), at the end of the test: exercise (Sal1, HR1) and 5 min after the test: recovery (Sat2, HR2). The increase in heart rate was defined as HR1-HR0 and the decrease in saturation as Sat0-Sat1. The results obtained before and after the PAH-specific treatment were analyzed and their effect on survival was assessed. Results: Fifteen of 29 patients were female (51.7%). The mean age was 127.2 +/- 44.8 months and the median follow-up time was 60 (12-156) months. Only pre-treatment HR1 was found associated with survival. The mean HR1 value of survivors was 122.8 +/- 18.4 and that of deceased 94.3 +/- 19.1 (p = 0.03). Post-treatment 6MWT was associated with survival. It was 453.3 +/- 96.5 in for survivors and 250 +/- 135.2 m for deceased (p = 0.02). Conclusion: Post-treatment 6MWT, FC and proBNP had prognostic value in pediatric patients with PAH. The decrease in saturation and increase in heart rate were not found to have a prognostic value. Pre-treatment HR1 was associated with survival. Identification of these prognostic factors at the beginning and throughout the treatment may be a guide for detecting the severity of the disease and follow-up.

引用

页码：1833 / 1840

页数：8

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