Changes in mood and health-related quality of life in Look AHEAD 6 years after termination of the lifestyle intervention

被引：7

作者：

Wadden, Thomas A. ^{[1
]}

Chao, Ariana M. ^{[2
]}

Anderson, Harelda ^{[3
,4
]}

Annis, Kirsten ^{[5
]}

Atkinson, Karen ^{[6
]}

Bolin, Paula ^{[3
,4
]}

Brantley, Phillip ^{[7
]}

Clark, Jeanne M. ^{[8
]}

Coday, Mace ^{[9
]}

Dutton, Gareth ^{[10
]}

Foreyt, John P. ^{[11
]}

Gregg, Edward W. ^{[12
]}

Hazuda, Helen P. ^{[13
]}

Hill, James O. ^{[10
]}

Hubbard, Van S. ^{[14
]}

Jakicic, John M. ^{[15
]}

Jeffery, Robert W. ^{[16
]}

Johnson, Karen C. ^{[9
,17
]}

Kahn, Steven E. ^{[6
]}

Knowler, William C. ^{[3
,4
]}

Korytkowski, Mary ^{[18
]}

Lewis, Cora E. ^{[19
]}

Laferrere, Blandine ^{[20
]}

Middelbeek, Roeland J. ^{[21
]}

Munshi, Medha N. ^{[21
]}

Nathan, David M. ^{[22
]}

Neiberg, Rebecca H. ^{[23
]}

Pilla, Scott J. ^{[8
]}

Peters, Anne ^{[24
]}

Pi-Sunyer, Xavier ^{[20
]}

Rejeski, Jack W. ^{[25
]}

Redmon, Bruce ^{[26
]}

Stewart, Tiffany ^{[7
]}

Vaughan, Elizabeth ^{[11
]}

Wagenknecht, Lynne E. ^{[27
]}

Walkup, Michael P. ^{[23
]}

Wing, Rena R. ^{[5
]}

Wyatt, Holly ^{[28
]}

Yanovski, Susan Z. ^{[14
]}

Zhang, Ping ^{[29
]}

机构：

[1] Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Biobehav Hlth Sci, Sch Nursing, Philadelphia, PA 19104 USA

[3] NIDDKD, Southwestern Amer Indian Ctr, Phoenix, AZ USA

[4] NIDDKD, Southwestern Amer Indian Ctr, Shiprock, NM USA

[5] Brown Univ, Dept Psychiat, Miriam Hosp, Alpert Med Sch, Providence, RI USA

[6] Univ Washington, Div Metab Endocrinol & Nutr, VA Puget Sound Hlth Care Syst, Seattle, WA USA

[7] Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA

[8] Johns Hopkins Univ, Div Gen Internal Med, Baltimore, MD USA

[9] Univ Tennessee, Dept Prevent Med, Hlth Sci Ctr, Memphis, TN USA

[10] Univ Alabama Birmingham, Sch Med, Dept Med, Birmingham, AL USA

[11] Baylor Coll Med, Dept Med, Houston, TX 77030 USA

[12] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[13] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX USA

[14] NIDDKD, Div Digest Dis & Nutr, NIH, Bethesda, MD USA

[15] Univ Pittsburgh, Dept Hlth & Phys Act, Sch Educ, Pittsburgh, PA USA

[16] Univ Minnesota, Div Epidemiol & Community Hlth, Sch Publ Hlth, Minneapolis, MN USA

[17] Univ Tennessee, Dept Med, Hlth Sci Ctr, Memphis, TN USA

[18] Univ Pittsburgh, Sch Med, Dept Med, Pittsburgh, PA 15213 USA

[19] Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA

[20] Columbia Univ, Dept Med, Vagelos Coll Phys & Surg, New York, NY USA

[21] Joslin Diabet Ctr, Boston, MA 02215 USA

[22] Harvard Univ, Diabet Ctr, Massachusetts Gen Hosp, Harvard Med Sch, Boston, MA USA

[23] Wake Forest Univ, Dept Biostat & Data Sci, Bowman Gray Sch Med, Winston Salem, NC USA

[24] Univ Southern Calif, Dept Med, Keck Sch Med, Los Angeles, CA USA

[25] Wake Forest Univ, Dept Hlth & Exercise Sci, Winston Salem, NC USA

[26] Univ Minnesota, Dept Med, Med Sch, Minneapolis, MN USA

[27] Wake Forest Sch Med, Dept Publ Hlth Sci, Winston Salem, NC USA

[28] Univ Colorado, Dept Med, Sch Med, Anschutz Med Campus, Aurora, CO USA

[29] CDCP, DDT Hlth Econ Workgrp Atlanta, Atlanta, GA USA

来源：

OBESITY | 2021年 / 29卷 / 08期

关键词：

CARDIOVASCULAR-DISEASE; ALL-CAUSE; DEPRESSION; OBESITY; ASSOCIATION; WEIGHT; INDIVIDUALS; MORTALITY; IMPACT; CARE;

D O I：

10.1002/oby.23191

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective The Action for Health in Diabetes (Look AHEAD) study previously reported that intensive lifestyle intervention (ILI) reduced incident depressive symptoms and improved health-related quality of life (HRQOL) over nearly 10 years of intervention compared with a control group (the diabetes support and education group [DSE]) in participants with type 2 diabetes and overweight or obesity. The present study compared incident depressive symptoms and changes in HRQOL in these groups for an additional 6 years following termination of the ILI in September 2012. Methods A total of 1,945 ILI participants and 1,900 DSE participants completed at least one of four planned postintervention assessments at which weight, mood (via the Patient Health Questionnaire-9), antidepressant medication use, and HRQOL (via the Medical Outcomes Scale, Short Form-36) were measured. Results ILI participants and DSE participants lost 3.1 (0.3) and 3.8 (0.3) kg [represented as mean (SE); p = 0.10], respectively, during the 6-year postintervention follow-up. No significant differences were observed between groups during this time in incident mild or greater symptoms of depression, antidepressant medication use, or in changes on the physical component summary or mental component summary scores of the Short Form-36. In both groups, mental component summary scores were higher than physical component summary scores. Conclusions Prior participation in the ILI, compared with the DSE group, did not appear to improve subsequent mood or HRQOL during 6 years of postintervention follow-up.

引用

页码：1294 / 1308

页数：15

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