The expressions of carbonic anhydrase 9 and vascular endothelial growth factor in astrocytic tumors predict a poor prognosis

被引:20
|
作者
Yoo, Heon [1 ]
Sohn, Seil [1 ]
Nam, Byung Ho [2 ]
Min, Hye Sook [3 ]
Jung, Eugene [1 ]
Shin, Sang Hoon [1 ]
Gwak, Ho-Shin [1 ]
Lee, Seung Hoon [1 ]
机构
[1] Natl Canc Ctr, Neurooncol Clin, Ctr Specif Organs Canc, Goyang 411769, Gyonggi, South Korea
[2] Natl Canc Ctr, Canc Registrat & Biostat Branch, Goyang 411769, Gyonggi, South Korea
[3] Natl Canc Ctr, Dept Pathol, Goyang 411769, Gyonggi, South Korea
关键词
carbonic anhydrase 9; hypoxia; glioma; vascular endothelial growth factor; SQUAMOUS-CELL CARCINOMA; CERVICAL-CANCER; HYPOXIA MARKER; TISSUE FACTORS; IX EXPRESSION; GLIOMA-CELLS; IN-VIVO; CA-IX; CARBONIC-ANHYDRASE-9; SURVIVAL;
D O I
10.3892/ijmm_00000427
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Hypoxia in the tumor microenvironment triggers a variety of genetic and adoptive responses that regulate tumor growth. Tumor hypoxia is often associated with a malignant phenotype, resistance to therapy, and poor survival. The objectives of this study were to evaluate the expressions of carbonic anhydrase 9 (CA9) and vascular endothelial growth factor (VEGF) in astrocytic gliomas and to relate patterns of expression with prognosis, that is with histological grade and survival. We investigated 78 World Health Organization (WHO) grade II, IQ, and IV astrocytic gliomas. CA9 expression was examined in paraffin-embedded sections by immunohistochemistry. Fourteen tumors were grade II, 30 were grade III, and 34 were grade IV. It was found that CA9 expression was significantly associated with a higher-grade histology (p<0.001). There were 3 CA9 positive tumors in grade II (21.4%), 10 in grade IR (33.3%), and 27 in grade IV (79.4%). For all tumors and WHO grade II, overall survival was found to be significantly dependent on CA9 expression (p=0.004, p=0.01). Furthermore, VEGF expression was found to be significantly related to tumor grade (p=0.02) and tended to be related to overall survival (p=0.1). However, no relation was found between the expression of CA9 and VEGF (p=0.17). Nevertheless, the expressions of CA9 and VEGF were found to be associated with tumor grade and possibly with survival. Further studies on a larger patient population are needed to determine the correlation between the expressions of CA9, and VEGF in astrocytic gliomas and clinical outcome.
引用
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页码:3 / 9
页数:7
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