Lipid modifications and membrane targeting of Gα

被引：0

作者：

Wedegaertner, PB ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Dept Microbiol & Immunol, Kimmel Canc Inst, Philadelphia, PA 19107 USA

来源：

BIOLOGICAL SIGNALS AND RECEPTORS | 1998年 / 7卷 / 02期

关键词：

palmitoylation; myristoylation; heterotrimeric G proteins; membrane localization;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

G protein alpha-subunits (G(alpha)) undergo palmitoylation and/or myristoylation. This review will focus on new insights into the function and regulation of these fatty acid modifications of G(alpha). Most importantly, I will examine lipid modifications of G(alpha) in the context of a two-signal model for membrane attachment, discuss recent advances in the identification of palmitoyl transferases, and highlight several controversial issues in this field.

引用

页码：125 / 135

页数：11

共 69 条

[1] BIOCHEMICAL-CHARACTERIZATION OF A PALMITOYL ACYLTRANSFERASE ACTIVITY THAT PALMITOYLATES MYRISTOYLATED PROTEINS [J].

BERTHIAUME, L ;

RESH, MD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (38) :22399-22405

[2] Understanding covalent modifications of proteins by lipids: Where cell biology and biophysics mingle [J].

Bhatnagar, RS ;

Gordon, JI .

TRENDS IN CELL BIOLOGY, 1997, 7 (01) :14-20

[3] ROLES OF LIPID MODIFICATIONS OF TRANSDUCIN SUBUNITS IN THEIR GDP-DEPENDENT ASSOCIATION AND MEMBRANE-BINDING [J].

BIGAY, J ;

FAUROBERT, E ;

FRANCO, M ;

CHABRE, M .

BIOCHEMISTRY, 1994, 33 (47) :14081-14090

[4] N-terminal binding domain of G alpha subunits: Involvement of amino acids 11-14 of G alpha(o) in membrane attachment [J].

Busconi, L ;

Boutin, PM ;

Denker, BM .

BIOCHEMICAL JOURNAL, 1997, 323 :239-244

[5] N-TERMINALLY MYRISTOYLATED RAS PROTEINS REQUIRE PALMITOYLATION OR A POLYBASIC DOMAIN FOR PLASMA-MEMBRANE LOCALIZATION [J].

CADWALLADER, KA ;

PATERSON, H ;

MACDONALD, SG ;

HANCOCK, JF .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (07) :4722-4730

[6]

CAMP LA, 1993, J BIOL CHEM, V268, P22566

[7]

CAMP LA, 1994, J BIOL CHEM, V269, P23212

[8] PROTEIN LIPIDATION IN CELL SIGNALING [J].

CASEY, PJ .

SCIENCE, 1995, 268 (5208) :221-225

[9]

Das AK, 1997, J BIOL CHEM, V272, P11021

[10]

DEGTYAREV MY, 1994, J BIOL CHEM, V269, P30898

← 1 2 3 4 5 6 7 →