Protein translocation: Checkpoint role for SRP GTPase activation

被引：10
|
作者：
Bange, Gert [1 ]
Wild, Klemens [1 ]
Sinning, Irmgard [1 ]
机构：
[1] Univ Heidelberg, Biochem Ctr, INF328, D-69120 Heidelberg, Germany
来源：
CURRENT BIOLOGY | 2007年 / 17卷 / 22期
关键词：
D O I：
10.1016/j.cub.2007.09.041
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Co-translational protein targeting by the signal recognition particle (SOD) relies on a complex series of structural rearrangements in the SRP and its receptor (SR). In order to precisely coordinate the individual steps, the GTPases of the SRP and the SR form a unique complex in which GTP hydrolysis is activated in a composite active site. A recent study provides new insights on the link between the GTPases and protein translocation.
引用
收藏
页码：R980 / R982
页数：3
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