The post thrombotic syndrome

被引：60

作者：

Kahn, Susan R. ^{[1
,2
,3
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机构：

[1] McGill Univ, Div Internal Med, Dept Med, Montreal, PQ H3T 1E2, Canada

[2] Jewish Gen Hosp, Ctr Clin Epidemiol & Community Studies, Montreal, PQ H3T 1E2, Canada

[3] Jewish Gen Hosp, Div Internal Med, Montreal, PQ H3T 1E2, Canada

来源：

THROMBOSIS RESEARCH | 2011年 / 127卷

关键词：

Deep venous thrombosis; Post-thrombotic syndrome; Risk factors; Women; Prognosis; Management; Prevention; Treatment; Catheter-directed thrombolysis; Compression stockings; Venoactive medications; DEEP VENOUS THROMBOSIS; POSTTHROMBOTIC SYNDROME; VEIN THROMBOSIS; COMPRESSION STOCKINGS; CONTROLLED-TRIAL; RISK-FACTORS; 1ST EPISODE; ULTRASONOGRAPHY; THROMBOEMBOLISM; INSUFFICIENCY;

D O I：

10.1016/S0049-3848(11)70024-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

More than one-third of women with deep venous thrombosis (DVT) will develop the postthrombotic syndrome (PTS), and 5-10% develop severe PTS, which can manifest as venous ulcers. Typical features of PTS include chronic pain, swelling, heaviness, edema and skin changes in the affected limb. The main risk factors for PTS are persistent leg symptoms one month after acute DVT, anatomically extensive DVT, recurrent ipsilateral DVT, obesity and older age. Use of compression stockings for two years after DVT appears to reduce the incidence and severity of PTS but issues remain regarding their use and effectiveness. The cornerstone of managing PTS is compression therapy, primarily using ECS. Venoactive medications such as aescin and rutosides may provide short term relief of PTS symptoms. Further studies to elucidate the pathophysiology of PTS, to identify clinical and biological risk factors and to test new preventive and therapeutic approaches to PTS are needed. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：S89 / S92

页数：4

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