Transition-Metal-Free Approach to Polysubstituted Furans

被引：25

作者：

You, Changming ^{[1
]}

Zhang, Zhenming ^{[1
]}

Tu, Yongliang ^{[1
]}

Tang, Hong ^{[1
]}

Wang, Yuanfeng ^{[1
]}

Long, Da ^{[1
]}

Zhao, Junfeng ^{[1
,2
]}

机构：

[1] Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Jiangxi, Peoples R China

[2] Guangzhou Med Univ, Sch Pharmaceut Sci, Guangzhou 511436, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 85卷 / 05期

基金：

中国国家自然科学基金;

关键词：

HIGHLY FUNCTIONALIZED BENZOFURANS; REGIOSELECTIVE SYNTHESIS; H FUNCTIONALIZATION; EFFICIENT; STRATEGY; TANDEM; HYDROXYPHENONES; CONSTRUCTION; CYCLIZATION;

D O I：

10.1021/acs.joc.9b03006

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient and straightforward strategy for the synthesis of 2,3-disubstituted and 2,3,5-trisubstituted furans via a base-promoted domino reaction of beta-keto compounds with vinyl dichlorides is described. This transition-metal-free approach proceeds under operationally simple reaction conditions featuring easily available starting materials, a broad substrate scope, and good functional group tolerance.

引用

页码：3902 / 3910

页数：9

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