Transition-Metal-Free Approach to Polysubstituted Furans

被引：24
作者：
You, Changming [1 ]
Zhang, Zhenming [1 ]
Tu, Yongliang [1 ]
Tang, Hong [1 ]
Wang, Yuanfeng [1 ]
Long, Da [1 ]
Zhao, Junfeng [1 ,2 ]
机构：
[1] Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Jiangxi, Peoples R China
[2] Guangzhou Med Univ, Sch Pharmaceut Sci, Guangzhou 511436, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 85卷 / 05期
基金：
中国国家自然科学基金;
关键词：
HIGHLY FUNCTIONALIZED BENZOFURANS; REGIOSELECTIVE SYNTHESIS; H FUNCTIONALIZATION; EFFICIENT; STRATEGY; TANDEM; HYDROXYPHENONES; CONSTRUCTION; CYCLIZATION;
D O I：
10.1021/acs.joc.9b03006
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient and straightforward strategy for the synthesis of 2,3-disubstituted and 2,3,5-trisubstituted furans via a base-promoted domino reaction of beta-keto compounds with vinyl dichlorides is described. This transition-metal-free approach proceeds under operationally simple reaction conditions featuring easily available starting materials, a broad substrate scope, and good functional group tolerance.
引用
收藏
页码：3902 / 3910
页数：9
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