Aspergilones A and B, two benzylazaphilones with an unprecedented carbon skeleton from the gorgonian-derived fungus Aspergillus sp.

被引：57

作者：

Shao, Chang-Lun ^{[1
]}

Wang, Chang-Yun ^{[1
]}

Wei, Mei-Yan ^{[2
]}

Gu, Yu-Cheng ^{[3
]}

She, Zhi-Gang ^{[4
]}

Qian, Pei-Yuan ^{[5
]}

Lin, Yong-Cheng ^{[4
]}

机构：

[1] Ocean Univ China, Sch Med & Pharm, Minist Educ China, Key Lab Marine Drugs, Qingdao 266003, Peoples R China

[2] Guangdong Med Coll, Sch Pharm, Dongguan 523808, Peoples R China

[3] Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England

[4] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China

[5] Hong Kong Univ Sci & Technol, Div Life Sci, Sect Marine Ecol & Biotechnol, KAUST Global Acad Partnership Program, Hong Kong, Hong Kong, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Marine-derived fungus; Aspergillus sp; Gorgonian Dichotella gemmacea; Aspergilone; X-ray analysis; Cytotoxicity; Antifouling activity; SOUTH CHINA SEA; METABOLITES; DIMER;

D O I：

10.1016/j.bmcl.2010.12.005

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two novel benzylazaphilone derivatives with an unprecedented carbon skeleton, aspergilone A (1), and its symmetrical dimer with a unique methylene bridge, aspergilone B (2), have been isolated from the culture broth of a marine-derived fungus Aspergillus sp. from a gorgonian Dichotella gemmacea. Their structures and relative stereochemistries of 1 and 2 were elucidated using a combination of NMR spectroscopy and X-ray crystallography. Compound 1 not only exhibited in vitro selective cytotoxicity but also showed potent antifouling activity. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：690 / 693

页数：4

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