Porous nanostructure controls kinetics, disposition and self-assembly structure of lipid digestion products

被引：33

作者：

Joyce, Paul ^{[1
]}

Barnes, Timothy J. ^{[1
]}

Boyd, Ben J. ^{[2
,3
]}

Prestidge, Clive A. ^{[1
]}

机构：

[1] Univ South Australia, Sch Pharm & Med Sci, City East Campus, Adelaide, SA 5000, Australia

[2] Monash Univ, Monash Inst Pharmaceut Sci, Drug Delivery Disposit & Dynam, Parkville Campus, Parkville, Vic 3052, Australia

[3] Monash Univ, ARC Ctr Excellence Convergent Bionano Sci & Techn, Parkville Campus, Parkville, Vic 3052, Australia

来源：

RSC ADVANCES | 2016年 / 6卷 / 82期

基金：

澳大利亚研究理事会;

关键词：

NUCLEAR-MAGNETIC-RESONANCE; ORDERED MESOPOROUS SILICA; LIPASE-MEDIATED DIGESTION; COMMON FORMULATION LIPIDS; WATER-SOLUBLE DRUGS; DELIVERY-SYSTEMS; PANCREATIC LIPASES; ORAL DELIVERY; SPECTRAL DATA; QCM-D;

D O I：

10.1039/c6ra16028j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A combination of proton nuclear magnetic resonance (H-1 NMR) and synchrotron small-angle X-ray scattering (sSAXS) was used to discriminate the speciation and structure evolution of lipolysis products for submicron lipid droplets and lipid loaded in porous silica particles. The free fatty acid (FFA)-to-glyceride ratio was controlled by confining medium-chain length triglycerides (MCT) in porous silica particles, which influenced the colloidal self-assembly structures formed within the lipolysis media. FFA and glycerides released during hydrolysis formed highly geometrically organised structures in a time-dependent manner. Structural transitions from coexisting emulsion droplets and micelles to lamellar structures, and finally to inverse hexagonal phase were observed during the digestion of lipid droplets. In contrast, when hosted in porous silica particles the digestion of lipids resulted in the self-assembly of a lamellar phase that was independent of digestion time. The evolution of structure during lipid digestion was dependent on lipolysis kinetics and the relative concentration of FFA to glycerides, which highlights important implications for the controlled delivery and absorption of lipophilic bioactives.

引用

页码：78385 / 78395

页数：11

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