Fasting Serum Fatty Acid-binding Protein 4 Level Positively Correlates with Metabolic Syndrome in Hemodialysis Patients

Background and Aims. Serum fatty acid-binding protein 4 (FABP4) level increases in patients with metabolic syndrome (MetS). The interrelationships between fasting FABP4 levels and MetS have not been analyzed in hemodialysis (HD) patients. Methods. Fasting blood samples were obtained from 101 chronic HD patients. MetS was defined according to the diagnostic criteria of the International Diabetes Federation. Results. In total, 48 HD patients (47.5%) had MetS. Fasting FABP4 levels positively correlated with MetS (p = 0.022). Univariate linear regression analysis showed that the pre-HD body weight (p < 0.001), waist circumference (p = 0.003), body mass index (p = 0.003), total cholesterol (TCH) (p < 0.001), triglyceride (TG) (p < 0.001), creatinine (p = 0.042), insulin level (p = 0.014), and homeostasis model assessment of insulin resistance (HOMA-IR; p = 0.015) were positively correlated with serum FABP4 levels, whereas high-density lipoprotein-cholesterol (HDL-C) (p = 0.049) and adiponectin level (p = 0.004) were negatively correlated with fasting serum FABP4 levels in HD patients. Conclusions. MetS was positively correlated with fasting FABP4 levels in our chronic HD patients. TG, TCH, and waist circumference were independent predictors of serum FABP4 levels in HD patients. (C) 2010 IMSS. Published by Elsevier Inc.