Reaction of S-nitrosothiols with ascorbate:: clear evidence of two reactions

被引：43

作者：

Holmes, AJ ^{[1
]}

Williams, DLH ^{[1
]}

机构：

[1] Univ Durham, Dept Chem, Durham DH1 3LE, England

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 16期

关键词：

D O I：

10.1039/a803983f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ascorbate reacts with S-nitrosothiols at pH 7.4 via two pathways, in which ascorbate (at low concentration) acts as a reducing agent generating Cu-I, and (at high concentration) acts as a nucleophile, attacking the nitroso group.

引用

页码：1711 / 1712

页数：2

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