Management of drug reaction with eosinophilia and systemic symptoms (DRESS)

被引：102

作者：

Descamps, V. ^{[1
]}

Ben Said, B. ^{[2
]}

Sassolas, B. ^{[3
]}

Truchetet, F. ^{[4
]}

Avenel-Audran, M. ^{[5
]}

Girardin, P. ^{[6
]}

Guinnepain, M-T ^{[7
]}

Mathelier-Fusade, P. ^{[8
]}

Assier, H. ^{[9
]}

Milpied, B. ^{[10
]}

Modiano, P. ^{[11
]}

Lebrun-Vignes, B. ^{[12
]}

Barbaud, A. ^{[13
]}

机构：

[1] Hop Bichat Claude Bernard, AP HP, Serv Dermatol, F-75877 Paris, France

[2] Hop Edouard Herriot, Serv Dermatol, F-69437 Lyon, France

[3] Hop Morvan, Serv Dermatol, F-29609 Brest, France

[4] Hop Bon Secours, Serv Dermatol, F-57038 Metz, France

[5] CHU Angers, Serv Dermatol, F-49033 Angers, France

[6] CHU Besancon, Serv Dermatol, F-25030 Besancon, France

[7] Hop Inst Pasteur, Serv Dermatol, F-75724 Paris 15, France

[8] Hop Tenon, AP HP, Serv Dermatol, F-75020 Paris, France

[9] Hop Henri Mondor, AP HP, Serv Dermatol, F-94010 Creteil, France

[10] Hop St Andre, Serv Dermatol, F-33075 Bordeaux, France

[11] Hop St Vincent de Paul, Serv Dermatol, F-59020 Lille, France

[12] Ctr Hosp Pitie Salpetriere, AP HP, Serv Pharmacol, F-75651 Paris 13, France

[13] Hop Fournier, Serv Dermatol, F-54035 Nancy, France

来源：

ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE | 2010年 / 137卷 / 11期

关键词：

Adverse cutaneous drug reaction; DRESS; Drug-induced hypersensitivity syndrome; Human Herpesvirus 6; Viral reactivation; HERPESVIRUS; 6; INFECTION; HYPERSENSITIVITY SYNDROME; REACTIVATION;

D O I：

10.1016/j.annder.2010.04.024

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Objective. - The management of drug-induced hypersensitivity syndrome or drug reaction with eosinophilia and systemic symptoms (DRESS) is not codified. Demonstration of the reactivation of Herpesviruses illustrates the specific pathophysiology of this syndrome. Proposals for the management of DRESS were elaborated by the cutaneous adverse drug reaction working group of the French Society of Dermatology to help with its management. Methods. - From a review of literature and the experience of the members of this group, consensual proposals were written about diagnostic criteria, tests, treatment options, and follow-up. These proposals will need to be validated in prospective studies. Results. - A decisional tree of treatment options is proposed, based on the severity of visceral manifestations. The importance of a rapid withdrawal of the culprit drug and of a long-term follow-up is underlined. Treatment will be adapted to the clinicobiological status (topical corticosteroid, systemic corticosteroid, intravenous gammaglobulins, antivirals). (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：703 / 708

页数：6

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