The multi-potentiality of skin-derived stem cells in pigs

被引：10
作者：
Zhao, Ming-Tao [1 ]
Prather, R. S. [1 ]
机构：
[1] Univ Missouri, Div Anim Sci, Columbia, MO 65201 USA
来源：
THERIOGENOLOGY | 2011年 / 75卷 / 08期
关键词：
Stem cell; Skin; Chimera; Somatic cell nuclear transfer; MYELINATING SCHWANN-CELLS; INTRINSIC DIFFERENCES; PROGENITOR CELLS; SELF-RENEWAL; IN-VITRO; PRECURSORS; DIFFERENTIATION; GENERATION; DERIVATION; ASTROCYTES;
D O I：
10.1016/j.theriogenology.2010.06.010
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Multipotent skin-derived stem cells represent neural-crest derived precursors which have neural and mesodermal potency and can generate neurons, glias, smooth muscle cells, and adipocytes. Transcriptional profiling studies show that both intrinsic programs and extrinsic signaling pathways mediate their neural and mesodermal potency. In addition, recent progress implies that skin-derived stem cells may have a broader developmental potency than previously expected, of which is their potential to generate germline cells in vitro. In this review, we discuss the transcriptional profiling of multipotency and neural crest-derived characteristics of skin-derived stem cells, and argue for their potential germ-line competency in the view of nuclear and cellular reprogramming. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：1372 / 1380
页数：9
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