Thermo and pH dual-responsive nanoparticles for anti-cancer drug delivery

被引：228
|
作者：
Zhang, Leyang
Guo, Rui
Yang, Mi
Jiang, Xiqun [1 ]
Liu, Baorui
机构：
[1] Nanjing Univ, Coll Chem & Chem Engn, Mesoscop Chem Lab, Nanjing 210093, Peoples R China
[2] Nanjing Univ, Coll Chem & Chem Engn, Dept Polymer Sci & Engn, Nanjing 210093, Peoples R China
[3] Nanjing Univ, Med Coll, Affiliated Drum Tower Hosp, Dept Oncol, Nanjing 210093, Peoples R China
来源：
ADVANCED MATERIALS | 2007年 / 19卷 / 19期
关键词：
D O I：
10.1002/adma.200601817
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Thermo and pH dual-responsive nanoparticles encapsulating an anticancer drug (paclitaxel) were assembled from a diblock copolymer comprised of a hydrophilic poly(N-isopropylacrylamide-co -acrylic acid) block and a hydrophobic polycaprolactone block. These nanoparticles aggregated at body temperature under a slightly acidic pH of 6.9 (see figure), and a faster drug release was found to be associated with higher temperature and lower pH, both of which are advantageous for tumor-targeted anti-caner drug delivery.
引用
收藏
页码：2988 / +
页数：6
相关论文
共 50 条
  • [41] Stimuli Responsive Nanoparticles for Controlled Anti-cancer Drug Release
    Tang, Qi
    Yu, Bing
    Gao, Lilong
    Cong, Hailin
    Song, Na
    Lu, Chenghao
    CURRENT MEDICINAL CHEMISTRY, 2018, 25 (16) : 1837 - 1866
  • [42] Design of dual stimuli responsive polymer modified magnetic nanoparticles for targeted anti-cancer drug delivery and enhanced MR imaging
    Bhattacharya, Dipsikha
    Behera, Birendra
    Sahu, Sumanta Kumar
    Ananthakrishnan, Rajakumar
    Maiti, Tapas Kumar
    Pramanik, Panchanan
    NEW JOURNAL OF CHEMISTRY, 2016, 40 (01) : 545 - 557
  • [43] Magnetic And pH Dual-Responsive Nanoparticles For Synergistic Drug-Resistant Breast Cancer Chemo/Photodynamic Therapy
    Wang, Dan
    Li, Xuefen
    Li, Xinfang
    Kang, Anfeng
    Sun, Linhong
    Sun, Miao
    Yang, Feng
    Xu, Congjian
    INTERNATIONAL JOURNAL OF NANOMEDICINE, 2019, 14 : 7665 - 7679
  • [44] Thermo and pH Dual-Responsive Materials for Controllable Oil/Water Separation
    Cao, Yingze
    Liu, Na
    Fu, Changkui
    Li, Kan
    Tao, Lei
    Feng, Lin
    Wei, Yen
    ACS APPLIED MATERIALS & INTERFACES, 2014, 6 (03) : 2026 - 2030
  • [45] Anti-cancer, pharmacokinetics and tumor localization studies of pH-, RF- and thermo-responsive nanoparticles
    Rejinold, N. Sanoj
    Thomas, Reju George
    Muthiah, Muthunarayanan
    Chennazhi, K. P.
    Manzoor, K.
    Park, In-Kyu
    Jeong, Yong Yeon
    Jayakumar, R.
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2015, 74 : 249 - 262
  • [46] Regulation of oligonucleotide adsorption by a thermo and pH dual-responsive copolymer layer
    Feng, Chao
    Mu, Jiang-xue
    Ren, Chun-lai
    PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2021, 23 (26) : 14296 - 14307
  • [47] Glucose and pH Dual-Responsive Nanogels for Efficient Protein Delivery
    Si, Xinghui
    Song, Wantong
    Yang, Shengcai
    Ma, Lili
    Yang, Chenguang
    Tang, Zhaohui
    MACROMOLECULAR BIOSCIENCE, 2019, 19 (09)
  • [48] β-cyclodextrin based dual-responsive multifunctional nanotheranostics for cancer cell targeting and dual drug delivery
    Das, Manita
    Solanki, Archana
    Joshi, Apeksha
    Devkar, Ranjitsinh
    Seshadri, Sriram
    Thakore, Sonal
    CARBOHYDRATE POLYMERS, 2019, 206 : 694 - 705
  • [49] Preparation of temperature-pH dual-responsive hydrogel from hydroxyethyl starch for drug delivery
    Jong, Kwanghyok
    Ju, Benzhi
    Kim, Ganghyok
    Kim, Kwangjin
    COLLOID AND POLYMER SCIENCE, 2023, 301 (05) : 455 - 464
  • [50] Synthesis of Imatinib-loaded chitosan-modified magnetic nanoparticles as an anti-cancer agent for pH responsive targeted drug delivery
    Ghezeli, Zahra Karimi
    Hekmati, Malak
    Veisi, Hojat
    APPLIED ORGANOMETALLIC CHEMISTRY, 2019, 33 (04)
12345