Thermo and pH dual-responsive nanoparticles for anti-cancer drug delivery

被引：228
|
作者：
Zhang, Leyang
Guo, Rui
Yang, Mi
Jiang, Xiqun [1 ]
Liu, Baorui
机构：
[1] Nanjing Univ, Coll Chem & Chem Engn, Mesoscop Chem Lab, Nanjing 210093, Peoples R China
[2] Nanjing Univ, Coll Chem & Chem Engn, Dept Polymer Sci & Engn, Nanjing 210093, Peoples R China
[3] Nanjing Univ, Med Coll, Affiliated Drum Tower Hosp, Dept Oncol, Nanjing 210093, Peoples R China
来源：
ADVANCED MATERIALS | 2007年 / 19卷 / 19期
关键词：
D O I：
10.1002/adma.200601817
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Thermo and pH dual-responsive nanoparticles encapsulating an anticancer drug (paclitaxel) were assembled from a diblock copolymer comprised of a hydrophilic poly(N-isopropylacrylamide-co -acrylic acid) block and a hydrophobic polycaprolactone block. These nanoparticles aggregated at body temperature under a slightly acidic pH of 6.9 (see figure), and a faster drug release was found to be associated with higher temperature and lower pH, both of which are advantageous for tumor-targeted anti-caner drug delivery.
引用
收藏
页码：2988 / +
页数：6
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