Epigenetic Modifications Associated with Maternal Anxiety during Pregnancy and Children's Behavioral Measures

被引：17

作者：

Cao-Lei, Lei ^{[1
]}

van den Heuvel, Marion I. ^{[2
]}

Huse, Klaus ^{[3
]}

Platzer, Matthias ^{[3
]}

Elgbeili, Guillaume ^{[1
]}

Braeken, Marijke A. K. A. ^{[4
]}

Otte, Renee A. ^{[5
]}

Witte, Otto W. ^{[6
]}

Schwab, Matthias ^{[6
]}

van den Bergh, Bea R. H. ^{[7
,8
]}

机构：

[1] Douglas Hosp, Schizophrenia & Neurodev Disorders Res Sect, Montreal, PQ H4H 1R3, Canada

[2] Tilburg Univ, Dept Cognit Neuropsychol, NL-5037 AB Tilburg, Netherlands

[3] Fritz Lipmann Inst, Genome Anal Grp, Leibniz Inst Aging, D-07745 Jena, Germany

[4] Hasselt Univ, Biomed Res Inst, Fac Rehabil Sci, Rehabil Res Ctr, B-3500 Hasselt, Belgium

[5] Philips Res, Dept Personal & Prevent Care, Family Care, NL-5656 AE Eindhoven, Netherlands

[6] Jena Univ Hosp, Hans Berger Dept Neurol, D-07740 Jena, Germany

[7] Univ Leuven, Hlth Psychol Res Grp, KU Leuven, B-3000 Leuven, Belgium

[8] Flemish Govt, Dept Welf Publ Hlth & Family, B-1030 Brussels, Belgium

来源：

CELLS | 2021年 / 10卷 / 09期

关键词：

DNA methylation; IGF2; H19; LINE1; maternal anxiety; interaction; mediation; sex-specific effects; RECEPTOR GENE NR3C1; DNA METHYLATION; PRENATAL STRESS; DEPRESSIVE SYMPTOMS; CENTRAL ADIPOSITY; DISORDER; EXPOSURE; SEX; PREVALENCE; CORTISOL;

D O I：

10.3390/cells10092421

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Epigenetic changes are associated with altered behavior and neuropsychiatric disorders and they modify the trajectory of aging. Maternal anxiety during pregnancy is a common environmental challenge for the fetus, causing changes in DNA methylation. Here, we determined the mediating role of DNA methylation and the moderating role of offspring sex on the association between maternal anxiety and children's behavioral measures. In 83 mother-child dyads, maternal anxiety was assessed in each trimester of pregnancy when the child was four years of age. Children's behavioral measures and children's buccal DNA methylation levels (NR3C1, IGF2/H19 ICR, and LINE1) were examined. Higher maternal anxiety during the third trimester was associated with more methylation levels of the NR3C1. Moderating effects of sex on the association between maternal anxiety and methylation were found for IGF2/H19 and LINE1 CpGs. Mediation analysis showed that methylation of NR3C1 could buffer the effects of maternal anxiety on children's behavioral measures, but this effect did not remain significant after controlling for covariates. In conclusion, our data support an association between maternal anxiety during pregnancy and DNA methylation. The results also underscore the importance of sex differences and timing effects. However, DNA methylation as underlying mechanism of the effect of maternal anxiety during pregnancy on offspring's behavioral measures was not supported.

引用

页数：19

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