Lower expression of sialic acid receptors in the cecum of silky fowl (Gallus gallus domesticus Brisson) compared to white leghorn

被引:6
作者
Han, Deping [1 ,2 ]
Hu, Yanxin [3 ]
Teng, Kedao [3 ]
Deng, Xuemei [1 ,2 ]
机构
[1] China Agr Univ, Minist Agr, Natl Engn Lab Anim Breeding, Beijing 100193, Peoples R China
[2] China Agr Univ, Minist Agr, Key Lab Anim Genet Breeding & Reprod, Beijing 100193, Peoples R China
[3] China Agr Univ, Coll Vet Med, Beijing 100193, Peoples R China
关键词
Silky Fowl; influenza virus; sialic acid-alpha-2,3-galactose receptor; sialic acid-alpha 6-galactose receptor; AVIAN INFLUENZA-VIRUS; H5N1; INFLUENZA; HONG-KONG; HUMAN AIRWAY; A VIRUS; CELLS; SPECIFICITY; CHICKENS; DUCKS; MICE;
D O I
10.3382/ps/pew065
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
Avian influenza virus has received increasing attention in recent years because of the potential for recombination with the human virus. Distributions of sialic acid receptors on target cells are determinants of the susceptibilities of different species to influenza virus infection. In this study, the distribution of sialic acid receptors in the respiratory and gastrointestinal tracts of Silky Fowl and White Leghorn chickens were compared. The results showed that sialic acid-alpha-2,3-galactose receptors and sialic acid-alpha 6-galactose receptors were both observed in Silky Fowl and White Leghorn, but fewer positive cells were detected in Silky Fowl with significant difference in the cecum. The lower abundance of sialic acid receptors likely results from the lower abundance of CD3 and F4/80 immune cells in the cecum of Silky Fowl.
引用
收藏
页码:1290 / 1295
页数:6
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