Iron-deficiency anemia and its genetic markers

被引：0

作者：

Safuanova, GS ^{[1
]}

Morozova, AA ^{[1
]}

Khusnutdinova, EK ^{[1
]}

Sultanaeva, ZM ^{[1
]}

Victorova, TN ^{[1
]}

机构：

[1] Bashkir State Med Univ, Ufa, Russia

来源：

METAL IONS IN BIOLOGY AND MEDICINE, VOL 7 | 2002年 / 7卷

关键词：

iron-deficiency anemia; genetic; genes; risk of disease; predisposition; combinations of genotypes;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The polymorphism of genes cytochrome P-4501A1 (CYP1A1), glutathione S-transferase M1 (GSTM1), N-acetyltransferase 2 (Nat2), angiotensin-converting enzyme (ACE) and activator of plasminogene (AP) has been investigated among 102 patients with iron-deficiency anemia and 105 practically healthy persons (controls). The increased frequency of mutant form of gene CYP1A1 and homozygous deletion of gene AP in patients with iron-deficiency anemia showed significant difference from that in healthy controls. There were detected combinations of genotypes on polymorph systems CYP1A1, GSTM1, Nat2, ACE and AP that are characterized for iron-deficiency anemia patients. It's possible to use them as genetic markers of disease.

引用

页码：409 / 411

页数：3