Update on MALT lymphomas

被引：90
作者：
Isaacson, PG [1 ]
机构：
[1] UCL, Dept Histopathol, London WC1E 6JJ, England
来源：
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2005年 / 18卷 / 01期
关键词：
MALT lymphoma; salivary gland lymphoma; Sjogrens syndrome; gastric lymphoma; Helicobacter pylori; bcl10; maltl;
D O I：
10.1016/j.beha.2004.08.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Gastric mucosa associated lymphoid tissue (MALT) lymphoma is a histologically distinct tumour derived from MALT acquired as a result of Helicobacter pylori infection. Eradication of H. pylori causes clinical regression of the lymphoma in 75% of cases. In seeking to identify those cases resistant to this therapy, and in the interests of further understanding the biology of MALT lymphoma, genetic alterations of MALT lymphomas have been investigated. Three translocations, t(11;18)(q21;q21), t(1;14)(p22;q32) and t(14;18)(q32;q21) are specifically associated with MALT lymphoma and the genes involved have been identified. T(I 1;18) results in a chimeric fusion between the AP12 and MALT1 genes and is specifically associated with gastric MALT lymphomas that do not respond to eradication of H. pylori. T(1;14) and t(14;18) deregulate BCL10 and MALT1 expression, respectively. These three chromosomal translocations that involve different genes appear to share common oncogenic properties by targeting the same nuclear factor kappa B (NF kappa B) oncogenic pathway.
引用
收藏
页码：57 / 68
页数：12
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