Antiviral Strategies for Pandemic and Seasonal Influenza

被引：9

作者：

Hedlund, Maria ^{[1
]}

Larson, Jeffrey L. ^{[1
]}

Fang, Fang ^{[1
]}

机构：

[1] NexBio Inc, San Diego, CA 92121 USA

来源：

VIRUSES-BASEL | 2010年 / 2卷 / 08期

基金：

美国国家卫生研究院;

关键词：

influenza virus; neuraminidase inhibitors; sialic acid; RNA polymerase; SIALIDASE FUSION PROTEIN; NEURAMINIDASE ACTIVE-SITE; IN-VITRO SELECTION; VIRUS-INFECTION; INTRAVENOUS ZANAMIVIR; T-705; FAVIPIRAVIR; INHIBITOR; RESISTANT; OSELTAMIVIR; DAS181;

D O I：

10.3390/v2081766

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

While vaccines are the primary public health response to seasonal and pandemic flu, short of a universal vaccine there are inherent limitations to this approach. Antiviral drugs provide valuable alternative options for treatment and prophylaxis of influenza. Here, we will review drugs and drug candidates against influenza with an emphasis on the recent progress of a host-targeting entry-blocker drug candidate, DAS181, a sialidase fusion protein.

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收藏

页码：1766 / 1781

页数：16

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