4-HYDROXY-2-QUINOLONES. 174. HYDROCHLORIDES OF [(ALKYLAMINO)ALKYL]AMIDES OF 1-ALLYL-4-HYDROXY-6,7-DIMETHOXY-2-OXO-1,2-DIHYDROQUINOLINE-3-CARBOXYLIC ACID - A NEW CLASS OF OPIOID RECEPTOR ANTAGONISTS

被引：5

作者：

Ukrainets, I. V. ^{[1
]}

Sidorenko, L. V. ^{[1
]}

Davidenko, A. A. ^{[2
]}

Yarosh, A. K. ^{[3
]}

机构：

[1] Natl Univ Pharm, UA-61002 Kharkov, Ukraine

[2] NI Pirogov Vinnitsa Natl Med Univ, UA-21018 Vinnitsa, Ukraine

[3] Ukraine Acad Med Sci, Inst Pharmacol & Toxicol, UA-03680 Kiev, Ukraine

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2010年 / 46卷 / 04期

关键词：

4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids; opioid receptor antagonists amidation; NALTREXONE; DEPENDENCE;

D O I：

10.1007/s10593-010-0529-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Hydrochlorides salts of [(alkylamino)alkyl]amides of 1-allyl-4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid were synthesized as potential biologically active compounds. Pharmacological testing showed promise for using these compounds to develop new highly efficient opioid receptor antagonists.

引用

页码：445 / 451

页数：7

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