How to assemble a capsid

被引：26

作者：

Sundquist, Wesley I. ^{[1
]}

Hill, Christopher P. ^{[1
]}

机构：

[1] Univ Utah, Sch Med, Dept Biochem, Salt Lake City, UT 84112 USA

来源：

CELL | 2007年 / 131卷 / 01期

关键词：

D O I：

10.1016/j.cell.2007.09.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Retroviral capsids are composed of hexagonal arrays of the viral CA protein. In this issue of Cell, Ganser-Pornillos et al. ( 2007) provide a molecular model of the hexagonal HIV-1 CA lattice obtained from a new electron cryomicroscopic reconstruction. This study reveals the three principal stabilizing interfaces in the capsid lattice and explains how two different classes of inhibitors can block capsid assembly.

引用

页码：17 / 19

页数：5

共 10 条

[1] Second-site suppressors of Rous sarcoma virus CA mutations: Evidence for interdomain interactions [J].

Bowzard, JB ;

Wills, JW ;

Craven, RC .

JOURNAL OF VIROLOGY, 2001, 75 (15) :6850-6856

[2] Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein [J].

Gamble, TR ;

Yoo, SH ;

Vajdos, FF ;

vonSchwedler, UK ;

Worthylake, DK ;

Wang, H ;

McCutcheon, JP ;

Sundquist, WI ;

Hill, CP .

SCIENCE, 1997, 278 (5339) :849-853

[3] Assembly and analysis of conical models for the HIV-1 core [J].

Ganser, BK ;

Li, S ;

Klishko, VY ;

Finch, JT ;

Sundquist, WI .

SCIENCE, 1999, 283 (5398) :80-83

[4]

GANSERPORNILLOS BK, 2007, CELL

[5] Structure of the amino-terminal core domain of the HIV-1 capsid protein [J].

Gitti, RK ;

Lee, BM ;

Walker, J ;

Summers, MF ;

Yoo, S ;

Sundquist, WI .

SCIENCE, 1996, 273 (5272) :231-235

[6]

KELLY BN, 2007, MOL BIOL 0815, DOI DOI 10.1016/J.JMB.2007.07.070

[7] Identification of novel interactions in HIV-1 capsid protein assembly by high-resolution mass spectrometry [J].

Lanman, J ;

Lam, TT ;

Barnes, S ;

Sakalian, M ;

Emmett, MR ;

Marshall, AG ;

Prevelige, PE .

JOURNAL OF MOLECULAR BIOLOGY, 2003, 325 (04) :759-772

[8] Image reconstructions of helical assemblies of the HIV-1CA protein [J].

Li, S ;

Hill, CP ;

Sundquist, WI ;

Finch, JT .

NATURE, 2000, 407 (6802) :409-413

[9] High-resolution structure of a retroviral capsid hexameric amino-terminal domain [J].

Mortuza, GB ;

Haire, LF ;

Stevens, A ;

Smerdon, SJ ;

Stoye, JP ;

Taylor, IA .

NATURE, 2004, 431 (7007) :481-485

[10] The HIV-1 capsid protein C-terminal domain in complex with a virus assembly inhibitor [J].

Ternois, F ;

Sticht, J ;

Duquerroy, S ;

Kräusslich, HG ;

Rey, FA .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2005, 12 (08) :678-682

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