Suppressive effects of germinated buckwheat on development of fatty liver in mice fed with high-fat diet

被引：24

作者：

Choi, I. ^{[1
]}

Seog, H. ^{[1
]}

Park, Y. ^{[1
]}

Kim, Y. ^{[1
]}

Choi, H. ^{[1
]}

机构：

[1] Korea Food Res Inst, Div Food Resource Utilizat, Songnam 463420, Kyunggi Do, South Korea

来源：

PHYTOMEDICINE | 2007年 / 14卷 / 7-8期

关键词：

germinated buckwheat (Fagopyrum spez.); anti-fatty liver activity; PPAR gamma; C/EBP alpha;

D O I：

10.1016/j.phymed.2007.05.002

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Effects of buckwheat germinated for 48 h in suppressing fatty liver were investigated using an animal study. Concentration of rutin was increased more than 10 times, with production of quercitrin and one newly formed flavonoid during 48 h germination. When an ethanol extract of germinated buckwheat was fed daily to C57BL/6 mice at 100 or 200mg/kg body wt, along with a high-fat diet, oral administration of germinated buckwheat caused significant reductions in TG and TC levels in the liver after 8 weeks. Oral administration of germinated buckwheat also down-regulated mRNA expressions of PPAR gamma and C/EBP alpha in hepatocytes, in a dose-dependent manner. These results suggest that germinated buckwheat has potent anti-fatty liver activities caused partially by suppressing the gene expression of certain adipogenic transcription factors like PPAR gamma and C/EBP alpha in hepatocytes. (c) 2007 Elsevier GmbH. All rights reserved.

引用

页码：563 / 567

页数：5

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