Dopaminergic Receptor Targeting in Multiple Sclerosis: Is There Therapeutic Potential?

被引：20
作者：
Melnikov, Mikhail [1 ,2 ,3 ]
Pashenkov, Mikhail [3 ]
Boyko, Alexey [1 ,2 ]
机构：
[1] Pirogov Russian Natl Res Med Univ, Dept Neurol Neurosurg & Med Genet, Moscow 117997, Russia
[2] Fed Med Biol Agcy Russia, Fed Ctr Brain Res & Neurotechnol, Dept Neuroimmunol, Moscow 117997, Russia
[3] Fed Med Biol Agcy Russia, Natl Res Ctr, Inst Immunol, Lab Clin Immunol, Moscow 115522, Russia
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 10期
基金：
俄罗斯科学基金会;
关键词：
dopamine; Th17; cells; neuroinflammation; psychoneuroimmunology; multiple sclerosis; CENTRAL-NERVOUS-SYSTEM; T-CELLS; DENDRITIC CELLS; TH17; CELLS; FATIGUE; ENCEPHALOMYELITIS; MACROPHAGES; CYTOKINE; IMMUNE; DIFFERENTIATION;
D O I：
10.3390/ijms22105313
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Dopamine is a neurotransmitter that mediates neuropsychological functions of the central nervous system (CNS). Recent studies have shown the modulatory effect of dopamine on the cells of innate and adaptive immune systems, including Th17 cells, which play a critical role in inflammatory diseases of the CNS. This article reviews the literature data on the role of dopamine in the regulation of neuroinflammation in multiple sclerosis (MS). The influence of dopaminergic receptor targeting on experimental autoimmune encephalomyelitis (EAE) and MS pathogenesis, as well as the therapeutic potential of dopaminergic drugs as add-on pathogenetic therapy of MS, is discussed.
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页数：11
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