Synthesis and antimicrobial activities of some isocoumarin and dihydroisocoumarin derivatives

被引：39
作者：
Hussain, M
Hussain, MT
Rama, NH [1 ]
Hameed, S
Malik, A
Khan, KM
机构：
[1] Quaid I Azam Univ, Dept Chem, Islamabad, Pakistan
[2] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem Sci, Karachi 75270, Pakistan
来源：
NATURAL PRODUCT RESEARCH | 2003年 / 17卷 / 03期
关键词：
isocoumarin derivatives; dihydroisocoumarin derivatives; synthesis; biological screening;
D O I：
10.1080/1057563021000040826
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A new series of the isocoumarin derivatives of ibuprofen, fluribiprofen, naproxen, valproic acid and 1-naphthoic acid have been synthesized via condensation of homophthalic acid with their respective acid chlorides. The conversion of the latter two isocoumarins into (dl)-3,4-dihydroisocoumarins has also been achieved. Most of the synthesized compounds showed antifungal and antibacterial activities.
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页码：207 / 214
页数：8
相关论文
共 22 条
[1]  
ALIEN GR, 1972, J MED CHEM, V15, P934
[2]  
ATANASOVA I, 1986, Patent No. 61238788
[3]  
ATTAURRAHMAN, 2001, BIOASSAY TECHNIQUES, P16
[4]   PHARMACOKINETICS AND TISSUE PENETRATION OF TICARCILLIN COMBINED WITH CLAVULANIC ACID [J].
BENNETT, S ;
WISE, R ;
WESTON, D ;
DENT, J .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1983, 23 (06) :831-834
[5]  
BILLINGHAM MEJ, 1981, BRIT J PHARMACOL, V72, P523
[6]   EFFECT OF THE 7-AMINO SUBSTITUENT ON THE INHIBITORY POTENCY OF MECHANISM-BASED ISOCOUMARIN INHIBITORS FOR PORCINE PANCREATIC AND HUMAN NEUTROPHIL ELASTASES - A 1.85-A X-RAY STRUCTURE OF THE COMPLEX BETWEEN PORCINE PANCREATIC ELASTASE AND 7-[(N-TOSYLPHENYLALANYL)AMINO]-4-CHLORO-3-METHOXYISOCOUMARIN [J].
HERNANDEZ, MA ;
POWERS, JC ;
GLINSKI, J ;
OLEKSYSZYN, J ;
VIJAYALAKSHMI, J ;
MEYER, EF .
JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (06) :1121-1129
[7]   SELECTIVE ISOCOUMARIN SERINE PROTEASE INHIBITORS BLOCK RNK-16 LYMPHOCYTE GRANULE-MEDIATED CYTOLYSIS [J].
HUDIG, D ;
ALLISON, NJ ;
KAM, CM ;
POWERS, JC .
MOLECULAR IMMUNOLOGY, 1989, 26 (08) :793-798
[8]   BIOTINYLATED ISOCOUMARINS, NEW INHIBITORS AND REAGENTS FOR DETECTION, LOCALIZATION, AND ISOLATION OF SERINE PROTEASES [J].
KAM, CM ;
ABUELYAMAN, AS ;
LI, ZZ ;
HUDIG, D ;
POWERS, JC .
BIOCONJUGATE CHEMISTRY, 1993, 4 (06) :560-567
[9]   MECHANISM-BASED ISOCOUMARIN INHIBITORS FOR HUMAN-LEUKOCYTE ELASTASE - EFFECT OF THE 7-AMINO SUBSTITUENT AND 3-ALKOXY GROUP IN 3-ALKOXY-7-AMINO-4-CHLOROISOCOUMARINS ON INHIBITORY POTENCY [J].
KERRIGAN, JE ;
OLEKSYSZYN, J ;
KAM, CM ;
SELZLER, J ;
POWERS, JC .
JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (03) :544-552
[10]  
Kovacs T, 1997, LIEBIGS ANN-RECL, P211, DOI 10.1002/jlac.199719970130
123