Enhancement of all-trans-retinoic acid efficiency in granulocytic differentiation of HL-60 cells by incorporation into low density lipoprotein

被引：0
|
作者：
Gueddari, N
Bobichon, H
Depierreux, C
Liautaud-Roger, F
Duriez, P
Dufer, J
Jardillier, JC
机构：
[1] UFR Pharm, Biochim Lab, F-51100 Reims, France
[2] Inst Jean Godinoi, F-51100 Reims, France
[3] Inst Pasteur, Dept Rech Lipoprot & Atherosclerose, F-59019 Lille, France
[4] Inst Pasteur, INSERM, U325, F-59019 Lille, France
来源：
INTERNATIONAL JOURNAL OF ONCOLOGY | 1998年 / 13卷 / 05期
关键词：
ATRA-LDL; HL-60; cell maturation; LDL receptor;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
All-trans-retinoic acid (ATRA) has been proven to lead to complete remission of acute promyelocytic leukemia by inducing differentiation into granulocytes except when an acquired resistance occurred. High levels of low density lipoprotein (LDL) receptor in cancer cells suggested the use of ATRA incorporated into LDL. 50% of HL-60 cell differentiation were obtained with 5 nmoles/l of ATRA-LDL compared to 150 moles/l of ATRA. Maximal differentiation (80%) was reached at 25 nmoles/l and 1,000 nmoles/l respectively. This higher efficiency suggests the involvement of LDL receptor in ATRA-LDL internalization and/or the protection of the drug, from eventual catabolism, by LDL particles.
引用
收藏
页码：1069 / 1075
页数：7
相关论文
共 50 条
  • [41] Granulocytic differentiation of HL-60 promyelocytic leukemia cells is associated with increased expression of Cul5
    Shaneen S. Baxter
    Lauren A. Carlson
    Alejandro M. S. Mayer
    Mary L. Hall
    Michael J. Fay
    In Vitro Cellular & Developmental Biology - Animal, 2009, 45 : 264 - 274
  • [42] Low-dose ionizing radiation effects on differentiation of HL-60 cells
    Savickiene, Jurate
    Treigyte, Grazina
    Aleksandraviciene, Ceslava
    Navakauskiene, Ruta
    CENTRAL EUROPEAN JOURNAL OF BIOLOGY, 2010, 5 (05): : 600 - 612
  • [43] REGULATION OF THE 28 KDA HEAT-SHOCK PROTEIN BY RETINOIC ACID DURING DIFFERENTIATION OF HUMAN LEUKEMIC HL-60 CELLS
    SPECTOR, NL
    MEHLEN, P
    RYAN, C
    HARDY, L
    SAMSON, W
    LEVINE, H
    NADLER, LM
    FABRE, N
    ARRIGO, AP
    FEBS LETTERS, 1994, 337 (02) : 184 - 188
  • [44] Induction of granulocytic differentiation in acute promyelocytic leukemia cells (HL-60) by water-soluble chitosan oligomer
    Pae, HO
    Seo, WG
    Kim, NY
    Oh, GS
    Kim, GE
    Kim, YH
    Kwak, HJ
    Yun, YG
    Jun, CD
    Chung, HT
    LEUKEMIA RESEARCH, 2001, 25 (04) : 339 - 346
  • [45] A NOVEL INTRACELLULAR ANTIGEN IN HL-60 CELLS THAT CHANGES IN MOLECULAR-WEIGHT AFTER GRANULOCYTIC AND MONOCYTIC DIFFERENTIATION
    KATSURA, Y
    SHIMOMURA, S
    TAKATANI, O
    SATO, N
    LEUKEMIA RESEARCH, 1995, 19 (09) : 613 - 620
  • [46] Induction of fructose 1,6-bisphosphatase in HL-60 leukemia cells by retinoic acid
    Mizunuma, H
    Tashima, Y
    BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL, 1998, 44 (03): : 481 - 487
  • [47] Stimulation of histamine H-2- (and H-1)-receptors activates Ca2+ influx in all-trans-retinoic acid-differentiated HL-60 cells independently of phospholipase C or adenylyl cyclase
    Burde, R
    Seifert, R
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1996, 353 (02) : 123 - 129
  • [48] Induction of the differentiation of HL-60 promyelocytic leukemia cells by L-ascorbic acid
    Kang, HK
    Suh, JH
    Lee, JJ
    Yoon, SH
    Hyun, JW
    Choi, SW
    Choi, JY
    Ryu, KH
    Chung, MH
    FREE RADICAL RESEARCH, 2003, 37 (07) : 773 - 779
  • [49] A NEW DIFFERENTIATION FACTOR FROM HL-60 CELL-CULTURE TREATED WITH RETINOIC ACID - ISOLATION AND SEQUENCING
    KOSTANYAN, IA
    ASTAPOVA, MV
    STAROVOITOVA, EV
    DRANITSYNA, SM
    LIPKIN, VM
    BIOORGANICHESKAYA KHIMIYA, 1995, 21 (04): : 243 - 248
  • [50] Potentiation of arsenic trioxide-induced apoptosis by retinoic acid in retinoic acid sensitive and resistant HL-60 myeloid leukemia cells
    Huang, XJ
    CHINESE MEDICAL JOURNAL, 2000, 113 (06) : 498 - 501
12345