Enhancement of all-trans-retinoic acid efficiency in granulocytic differentiation of HL-60 cells by incorporation into low density lipoprotein

被引：0
|
作者：
Gueddari, N
Bobichon, H
Depierreux, C
Liautaud-Roger, F
Duriez, P
Dufer, J
Jardillier, JC
机构：
[1] UFR Pharm, Biochim Lab, F-51100 Reims, France
[2] Inst Jean Godinoi, F-51100 Reims, France
[3] Inst Pasteur, Dept Rech Lipoprot & Atherosclerose, F-59019 Lille, France
[4] Inst Pasteur, INSERM, U325, F-59019 Lille, France
来源：
INTERNATIONAL JOURNAL OF ONCOLOGY | 1998年 / 13卷 / 05期
关键词：
ATRA-LDL; HL-60; cell maturation; LDL receptor;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
All-trans-retinoic acid (ATRA) has been proven to lead to complete remission of acute promyelocytic leukemia by inducing differentiation into granulocytes except when an acquired resistance occurred. High levels of low density lipoprotein (LDL) receptor in cancer cells suggested the use of ATRA incorporated into LDL. 50% of HL-60 cell differentiation were obtained with 5 nmoles/l of ATRA-LDL compared to 150 moles/l of ATRA. Maximal differentiation (80%) was reached at 25 nmoles/l and 1,000 nmoles/l respectively. This higher efficiency suggests the involvement of LDL receptor in ATRA-LDL internalization and/or the protection of the drug, from eventual catabolism, by LDL particles.
引用
收藏
页码：1069 / 1075
页数：7
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