Novel construction of diversely functionalized N-heteroaryl-2-pyridones via copper(II)-catalyzed [3+2+1] annulation

被引：15

作者：

Akhtar, Muhammad Saeed ^{[1
]}

Shim, Jae-Jin ^{[1
]}

Kim, Sung Hong ^{[2
]}

Lee, Yong Rok ^{[1
]}

机构：

[1] Yeungnam Univ, Sch Chem Engn, Gyongsan 712749, South Korea

[2] Korea Basic Sci Inst, Daegu Ctr, Anal Res Div, Daegu 702701, South Korea

来源：

NEW JOURNAL OF CHEMISTRY | 2017年 / 41卷 / 21期

关键词：

IDIOPATHIC PULMONARY-FIBROSIS; CATALYZED COUPLING REACTION; CONGESTIVE-HEART-FAILURE; SUBSTITUTED; 2-PYRIDONES; EFFICIENT SYNTHESIS; DERIVATIVES; PYRIDONES; AGENTS; BENZANNULATION; INHIBITORS;

D O I：

10.1039/c7nj03013d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A facile and novel one-pot construction of diversely functionalized N-heteroaryl-2-pyridones is achieved by Cu(OTf)(2)-catalyzed [3+2+1] annulation of various 2-aminopyridines and beta-enamino esters. The [3+2+1] annulation proceeds via domino two Michael additions/elimination/isomerization/intramolecular cyclization.

引用

页码：13027 / 13035

页数：9

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