An autoantibody to C1-inhibitor recognizes the reactive center of the inhibitor

被引：13
作者：
Donaldson, VH
Wagner, CJ
Davis, AE
机构：
[1] UNIV CINCINNATI,COLL MED,DEPT PEDIAT,CINCINNATI,OH 45267
[2] UNIV CINCINNATI,COLL MED,DEPT MED,CINCINNATI,OH 45267
来源：
JOURNAL OF LABORATORY AND CLINICAL MEDICINE | 1996年 / 127卷 / 02期
关键词：
D O I：
10.1016/S0022-2143(96)90083-9
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
An autoantibody to <C(1)over bar>-inhibitor produced a clinical disorder resembling that of patients with hereditary angioneurotic edema. The antibody could not interact with <C(1)over bar>-inhibitor after exposure to synthetic peptides representing the primary structure of the reactive center region of the protein. Therefore the antibody recognized this domain of the inhibitor, and ii probably impaired the function of <C(1)over bar>-inhibitor by altering its conformational properties.
引用
收藏
页码：229 / 232
页数：4
相关论文
共 12 条
[1]  
[Anonymous], [No title captured]
[2]  
ASSIMEH SN, 1974, J IMMUNOL, V113, P225
[3]  
BING DH, 1971, J IMMUNOL, V107, P1243
[4]   HUMAN C1BAR INHIBITOR - PRIMARY STRUCTURE, CDNA CLONING, AND CHROMOSOMAL LOCALIZATION [J].
BOCK, SC ;
SKRIVER, K ;
NIELSEN, E ;
THOGERSEN, HC ;
WIMAN, B ;
DONALDSON, VH ;
EDDY, RL ;
MARRINAN, J ;
RADZIEJEWSKA, E ;
HUBER, R ;
SHOWS, TB ;
MAGNUSSON, S .
BIOCHEMISTRY, 1986, 25 (15) :4292-4301
[5]   C1 INHIBITOR HINGE REGION MUTATIONS PRODUCE DYSFUNCTION BY DIFFERENT MECHANISMS [J].
DAVIS, AE ;
AULAK, K ;
PARAD, RB ;
STECKLEIN, HP ;
ELDERING, E ;
HACK, CE ;
KRAMER, J ;
STRUNK, RC ;
BISSLER, J ;
ROSEN, FS .
NATURE GENETICS, 1992, 1 (05) :354-358
[6]   HUMAN INHIBITOR OF THE 1ST COMPONENT OF COMPLEMENT, C1 - CHARACTERIZATION OF CDNA CLONES AND LOCALIZATION OF THE GENE TO CHROMOSOME-11 [J].
DAVIS, AE ;
WHITEHEAD, AS ;
HARRISON, RA ;
DAUPHINAIS, A ;
BRUNS, GAP ;
CICARDI, M ;
ROSEN, FS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (10) :3161-3165
[7]  
Donaldson V H, 1993, Int Rev Immunol, V10, P1, DOI 10.3109/08830189309051168
[8]  
DONALDSON VH, 1992, J LAB CLIN MED, V119, P397
[9]  
DONALDSON VH, 1970, J IMMUNOL, V104, P1388
[10]   A MODIFICATION OF AN AFFINITY PROCEDURE FOR PURIFICATION OF HUMAN C(1)OVER-BAR INHIBITOR THAT PROVIDES A HOMOGENEOUS STABLE PREPARATION [J].
DONALDSON, VH ;
FALCONIERI, MW .
JOURNAL OF IMMUNOLOGICAL METHODS, 1993, 157 (1-2) :101-104
12