Fulminant type 1 diabetes mellitus associated with Coxsackievirus type B1 infection during pregnancy: a case report

被引：18

作者：

Hayakawa, Takahiro ^{[1
]}

Nakano, Yoshio ^{[1
]}

Hayakawa, Kana ^{[1
]}

Yoshimatu, Hiroaki ^{[1
]}

Hori, Yoshikazu ^{[1
]}

Yamanishi, Kazuki ^{[1
]}

Yamanishi, Hirofumi ^{[1
]}

Ota, Takayuki ^{[1
]}

Fujimoto, Tokuzo ^{[1
]}

机构：

[1] Kinan Hosp, Dept Internal Med, 46-70 Shinjo, Wakayama 6468588, Japan

来源：

JOURNAL OF MEDICAL CASE REPORTS | 2019年 / 13卷 / 01期

关键词：

Fulminant type 1 diabetes mellitus; Coxsackievirus B1; Pregnancy; Antiviral antibody; NATIONWIDE SURVEY;

D O I：

10.1186/s13256-019-2130-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Fulminant type 1 diabetes is characterized by an intrinsic insulin deficiency resulting from the severe destruction of pancreatic beta cells and it rapidly leads to ketoacidosis. However, the association between fulminant type 1 diabetes in pregnancy and specific viral infections has not been reported. Case presentation The patient in this study was a 31-year-old Japanese woman, and at 30 weeks of pregnancy she was admitted with marked fatigue. Fetal bradycardia was noted, and the child was delivered by emergency cesarean section but was stillborn. The maternal blood sugar level was high (427 mg/dL), but the glycated hemoglobin value was 6.2%; therefore, fulminant type 1 diabetes was suspected. Serum antibody testing confirmed a Coxsackievirus B1 infection. The patient in this case had fulminant type 1 diabetes in pregnancy associated with Coxsackievirus B1. Conclusion This case highlights that fulminant type 1 diabetes in pregnancy may be associated with Coxsackievirus B1 infection.

引用

页数：4

共 12 条

[1]

Akatsuka Hajime, 2009, Diabetes Res Clin Pract, V84, pe50, DOI 10.1016/j.diabres.2009.03.009

[2] NEW LOOK AT INFECTIOUS DISEASES - ENTEROVIRUS INFECTIONS [J].

BROWN, EH .

BRITISH MEDICAL JOURNAL, 1973, 2 (5859) :169-171

[3] Fulminant type 1 diabetes: a novel clinical entity requiring special attention by all medical practitioners [J].

Hanafusa, Toshiaki ;

Imagawa, Akihisa .

NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM, 2007, 3 (01) :36-45

[4] Developing a vaccine for type 1 diabetes by targeting coxsackievirus B [J].

Hyoety, Heikki ;

Leon, Francisco ;

Knip, Mikael .

EXPERT REVIEW OF VACCINES, 2018, 17 (12) :1071-1083

[5] Viruses in type 1 diabetes [J].

Hyoty, Heikki .

PEDIATRIC DIABETES, 2016, 17 :56-64

[6] Developing a vaccine for Type 1 diabetes through targeting enteroviral infections [J].

Hyoty, Heikki ;

Knip, Mikael .

EXPERT REVIEW OF VACCINES, 2014, 13 (08) :989-999

[7] Fulminant type 1 diabetes - A nationwide survey in Japan [J].

Imagawa, A ;

Hanafusa, T ;

Uchigata, Y ;

Kanatsuka, A ;

Kawasaki, E ;

Kobayashi, T ;

Shimada, A ;

Shimizu, I ;

Toyoda, T ;

Maruyama, T ;

Makino, H .

DIABETES CARE, 2003, 26 (08) :2345-2352

[8] A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies. [J].

Imagawa, A ;

Hanafusa, T ;

Miyagawa, J ;

Matsuzawa, Y .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (05) :301-307

[9] Fulminant Type 1 Diabetes Mellitus Associated with Coxsackie Virus Type A2 Infection: A Case Report and Literature Review [J].

Ohara, Nobumasa ;

Kaneko, Masanori ;

Nishibori, Takeaki ;

Sato, Kazuhiro ;

Furukawa, Tatsuo ;

Koike, Tadashi ;

Sone, Hirohito ;

Kaneko, Kenzo ;

Kamoi, Kyuzi .

INTERNAL MEDICINE, 2016, 55 (06) :643-646

[10] Clinical and immunogenetic characteristics of fulminant type 1 diabetes associated with pregnancy [J].

Shimizu, I ;

Makino, H ;

Imagawa, A ;

Iwahashi, H ;

Uchigata, Y ;

Kanatsuka, A ;

Kawasaki, E ;

Kobayashi, T ;

Shimada, A ;

Maruyama, T ;

Hanafusa, T .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (02) :471-476

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