Amycolamycins A and B, Two Enediyne-Derived Compounds from a Locust-Associated Actinomycete

被引：32

作者：

Ma, Shi Ying ^{[1
]}

Xiao, Yong Sheng ^{[1
]}

Zhang, Bo ^{[1
]}

Shao, Fen Li ^{[1
]}

Guo, Zhi Kai ^{[3
]}

Zhang, Juan Juan ^{[1
]}

Jiao, Rui Hua ^{[1
]}

Sun, Yang ^{[1
]}

Xu, Qiang ^{[1
]}

Tan, Ren Xiang ^{[1
,2
]}

Ge, Hui Ming ^{[1
]}

机构：

[1] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China

[2] Nanjing Univ Chinese Med, State Key Lab Cultivat Base TCM Qual & Efficacy, Nanjing 210023, Jiangsu, Peoples R China

[3] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Hainan, Peoples R China

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 22期

关键词：

BIOSYNTHETIC GENE-CLUSTER; SPOROLIDE-B; IMMUNOSUPPRESSIVE POLYKETIDES; DALDINIA-ESCHSCHOLZII; ANTITUMOR ANTIBIOTICS; GENOMICS;

D O I：

10.1021/acs.orglett.7b03113

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two novel enediyne-derived natural products, amycolamycins A and B (1- and 2); were characterized from a locust-associated actinomycete Amycolatopsis sp. HCa4. Amycolamycins A and B contain a unique 2-(cyclopenta[a]-inden-5-yl)oxirane core with suspected enediyne polyketide biosynthetic origin. Sequencing and analysis of the acm biosynthetic gene cluster allowed us to propose the biosynthetic pathway of 1 and 2. Moreover, amycolamycin A (1) was selectively cytotoxic to the M231 breast cancer cell line.

引用

页码：6208 / 6211

页数：4

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