Selective synthesis of 2-substituted 4-carboxy oxazoles, thiazoles and thiazolidines from serine or cysteine amino acids

被引：23

作者：

Di Credico, Barbara ^{[1
]}

Reginato, Gianna ^{[1
]}

Gonsalvi, Luca ^{[1
]}

Peruzzini, Maurizio ^{[1
]}

Rossin, Andrea ^{[1
]}

机构：

[1] CNR, Ist Chim Composti Organometall, ICCOM, I-50019 Sesto Fiorentino, Firenze, Italy

来源：

TETRAHEDRON | 2011年 / 67卷 / 01期

关键词：

Carboxy thiazoles; Carboxy oxazoles; Microwave activation; Multidentate ligands; ORGANIC-SYNTHESIS; DERIVATIVES; ANALOGS; OXIDATION; EFFICIENT; DESIGN; AGENTS;

D O I：

10.1016/j.tet.2010.09.104

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of new 4-carboxy oxazoles, thiazoles and thiazolidines by condensation of serine or cysteine with aldehydes or acids is described. Due to the optimization of a mild and selective procedure, which takes advantage of the positive effect of microwave irradiation on the MnO2 mediated oxidation step, the 2-substituted-4-carboxy derivatives can be obtained in multi-gram scale. Examples of coordination chemistry to Ni(II) and Co(II) are described. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：267 / 274

页数：8

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