Sex and Gender in Glomerular Disease

被引：14

作者：

Beckwith, Hannah ^{[1
,2
]}

Lightstone, Liz ^{[1
,2
]}

McAdoo, Steve ^{[1
,2
]}

机构：

[1] Imperial Coll London, Dept Renal Med, Hammersmith Hosp Campus,Du Cane Rd, London W12 0HS, England

[2] Imperial Coll Healthcare NHS Trust, London, England

来源：

SEMINARS IN NEPHROLOGY | 2022年 / 42卷 / 02期

关键词：

Sex; gender; glomerulonephritis; glomerular disease; autoimmunity; SYSTEMIC-LUPUS-ERYTHEMATOSUS; IGA NEPHROPATHY; WEGENERS-GRANULOMATOSIS; HYDROCARBON EXPOSURE; RENAL-FUNCTION; NEPHRITIS; ANCA; ESTROGEN; GLOMERULONEPHRITIS; 17-BETA-ESTRADIOL;

D O I：

10.1016/j.semnephrol.2022.04.008

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

There is increasing understanding that a multifaceted interplay of sex-dependent genetic and immune dysregulation underpins the development of glomerular disorders. Regional and ethnic variations in glomerular disease incidence make delineating the effects of sex and gender on disease pathophysiology more complex, but there is a marked paucity of research in this area. This review article presents a summary of the current understanding of sex and gender in glomerular disease, highlighting the broader effects of sex and gender on autoimmunity, clinical presentations, and pathophysiology of individual glomerular diseases, as well as exploring sex, gender, and glomerular disease within a wider socioenvironmental context. It is important to specifically consider the effects of sex and gender when presenting and analyzing clinical and scientific studies on glomerular disease. Failure to do so risks promoting disparities within health care provision, neglecting opportunities to identify sex-specific biomarkers, and potentially hindering the development of sex-specific therapies. (C) 2022 The Author(s). Published by Elsevier Inc.

引用

页码：185 / 196

页数：12

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