Palladium/N-Heterocyclic Carbene Catalyzed Mono- and Double-Cyanation of Aryl Halides Using Potassium Ferrocyanide Trihydrate under Aerobic Conditions

被引：5

作者：

Xu, Zhicheng ^{[1
,2
]}

Xiao, Yunqing ^{[1
,2
]}

Ding, Hong ^{[3
]}

Cao, Changsheng ^{[1
,2
]}

Li, Haitao ^{[1
,2
]}

Pang, Guangsheng ^{[3
]}

Shi, Yanhui ^{[1
,2
]}

机构：

[1] Jiangsu Normal Univ, Sch Chem & Chem Engn, Xuzhou 221116, Jiangsu, Peoples R China

[2] Jiangsu Normal Univ, Jiangsu Key Lab Green Synthet Chem Funct Mat, Xuzhou 221116, Jiangsu, Peoples R China

[3] Jilin Univ, State Key Lab Inorgan Synth & Preparat Chem, Changchun 130012, Jilin, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2015年 / 47卷 / 11期

基金：

中国国家自然科学基金;

关键词：

cyanation; N-heterocyclic carbene; palladium catalysis; potassium ferrocyanide; aerobic conditions; GENERATED IN-SITU; AROMATIC HALIDES; BROMIDES; COMPLEXES; EFFICIENT; ROBUST; MILD; HEXACYANOFERRATE(II); SUBSTITUTION; DESIGN;

D O I：

10.1055/s-0034-1379899

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical palladium/N-heterocyclic carbene catalyzed procedure for the mono-and double-cyanation of aryl halides is described using inexpensive, easy-to-handle and nontoxic potassium ferrocyanide trihydrate {K-4[Fe(CN)(6)] center dot 3H(2)O} as the cyanating agent. The reaction does not require an anhydrous solvent, or the exclusion of air or moisture. A variety of electron-rich and electron-deficient aryl halides are efficiently converted into their corresponding nitriles and dicarbonitriles.

引用

页码：1560 / 1566

页数：7

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