Effect of water-soluble carriers on naproxen release from hydrophilic matrix tablets

被引：0
|
作者：
Amaral, MH [1 ]
Lobo, JMS [1 ]
Ferreira, DC [1 ]
机构：
[1] Univ Porto, Fac Farm, Ctr Tecnol Medicamento, P-4050047 Oporto, Portugal
来源：
STP PHARMA SCIENCES | 2003年 / 13卷 / 03期
关键词：
naproxen; hydroxypropyl methylcellulose; lactose; polyethylene glycol; solid dispersion;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Naproxen, a poor water-soluble drug, was taken as a model to study the influence of water-soluble carriers (lactose and polyethylene glycol) on drug release from hydroxypropyl methylcellulose (HPMC) matrix tablets. This study demonstrated that the release profile of naproxen from HPMC matrices remained unchanged when lactose or polyethylene glycol 4000 were added to the same drug and polymer concentrations. These data were confirmed by the results of water uptake studies. Due to the higher water solubility of PEG4000, the erosion of compressed mixtures of HPMC K100M/PEG4000 (1: 1) was higher than the erosion of tablets containing the same proportion of lactose.
引用
收藏
页码：191 / 194
页数：4
相关论文
共 50 条
  • [21] Naproxen availability from variable-dose and weight sustained-release tablets
    Amaral, MH
    Lobo, JMS
    Ferreira, DC
    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2001, 27 (03) : 221 - 225
  • [22] Controlled and complete release of a model poorly water-soluble drug, prednisolone, from hydroxypropyl methylcellulose matrix tablets using (SBE)7M-β-cyclodextrin as a solubilizing agent
    Rao, VM
    Haslam, JL
    Stella, VJ
    JOURNAL OF PHARMACEUTICAL SCIENCES, 2001, 90 (07) : 807 - 816
  • [23] Effect of anionic polymers on the release of propranolol hydrochloride from matrix tablets
    Takka, S
    Rajbhandari, S
    Sakr, A
    EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2001, 52 (01) : 75 - 82
  • [24] Effect of ion exchange resins on the drug release from matrix tablets
    Sriwongjanya, M
    Bodmeier, R
    EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 1998, 46 (03) : 321 - 327
  • [25] The effect of chemical heterogeneity of HPMC on polymer release from matrix tablets
    Viriden, Anna
    Wittgren, Bengt
    Andersson, Thomas
    Larsson, Anette
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2009, 36 (4-5) : 392 - 400
  • [26] The effect of substitution pattern of HPMC on polymer release from matrix tablets
    Viriden, Anna
    Larsson, Anette
    Wittgren, Bengt
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2010, 389 (1-2) : 147 - 156
  • [27] A Water-Soluble Chitosan Derivative for the Release of Bioactive Deferoxamine
    Michailidou, Georgia
    Li, Yupeng
    Zamboulis, Alexandra
    Karlioti, Georgia
    Meimaroglou, Despoina
    Pantopoulos, Kostas
    Bikiaris, Dimitrios N.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (02)
  • [28] THE EFFECT OF POLYMER PROPERTIES ON THE RELEASE MECHANISMS OF DICLOFENAC SODIUM FROM CONTROLLED RELEASE MATRIX TABLETS
    Zimmer, Lukasz
    Kasperek, Regina
    Kierys, Agnieszka
    Grochowicz, Marta
    Poleszak, Ewa
    ACTA POLONIAE PHARMACEUTICA, 2018, 75 (01): : 169 - 182
  • [29] Polyethylene oxide and its controlled release properties in hydrophilic matrix tablets for oral administration
    Vanza, Jigar D.
    Patel, Rashmin B.
    Dave, Richa R.
    Patel, Mrunali R.
    PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2020, 25 (10) : 1169 - 1187
  • [30] Crystalline properties of carbamazepine in sustained release hydrophilic matrix tablets based on hydroxypropyl methylcellulose
    Katzhendler, I
    Azoury, R
    Friedman, M
    JOURNAL OF CONTROLLED RELEASE, 1998, 54 (01) : 69 - 85
12345