Maternal vitamin and iron supplementation and risk of infant leukaemia: a report from the Children's Oncology Group

被引：7

作者：

Linabery, A. M. ^{[1
]}

Puumala, S. E. ^{[1
]}

Hilden, J. M. ^{[2
]}

Davies, S. M. ^{[3
]}

Heerema, N. A. ^{[4
]}

Roesler, M. A. ^{[1
]}

Ross, J. A. ^{[1
,5
]}

机构：

[1] Univ Minnesota, Div Pediat Epidemiol & Clin Res, Dept Pediat, Minneapolis, MN 55455 USA

[2] Peyton Manning Childrens Hosp St Vincent, Indianapolis, IN 46260 USA

[3] Cincinnati Childrens Hosp, Med Ctr, Div Hematol Oncol, Cincinnati, OH 45229 USA

[4] Ohio State Univ, Dept Pathol, Columbus, OH 43210 USA

[5] Univ Minnesota, Mason Canc Ctr, Minneapolis, MN 55455 USA

来源：

BRITISH JOURNAL OF CANCER | 2010年 / 103卷 / 11期

基金：

美国国家卫生研究院;

关键词：

epidemiology; infants; vitamin; leukaemia; ACUTE LYMPHOBLASTIC-LEUKEMIA; ACID FOOD FORTIFICATION; FOLIC-ACID; CHILDHOOD-CANCER; MEDICATION USE; PREGNANCY; FOLATE; DNA; MALIGNANCIES; LESSONS;

D O I：

10.1038/sj.bjc.6605957

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BACKGROUND: Prenatal supplementation has been inversely associated with childhood, but not with infant, leukaemia. METHODS: Mothers of 443 cases of infant leukaemia diagnosed during 1996-2006 and 324 frequency-matched controls completed interviews. Associations were evaluated by unconditional logistic regression. RESULTS: We observed no associations between prenatal vitamin (odds ratio (OR) = 0.79, 95% confidence interval (CI): 0.44-1.42) or iron supplementation (OR = 1.07, 95% CI: 0.75-1.52) and infant leukaemia after adjustment for race/ethnicity and income. Similar results were observed for leukaemia subtypes analysed separately. CONCLUSION: The observed null associations may be attributable to high supplementation rates and/or national fortification programmes. British Journal of Cancer (2010) 103, 1724-1728. doi:10.1038/sj.bjc.6605957 www.bjcancer.com Published online 26 October 2010 (C) 2010 Cancer Research UK

引用

页码：1724 / 1728

页数：5

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