Natural products analogs as scaffolds for supramolecular and combinatorial chemistry

被引：73

作者：

Mink, D

Mecozzi, S

Rebek, J ^{[1
]}

机构：

[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 32期

基金：

加拿大自然科学与工程研究理事会; 美国国家卫生研究院;

关键词：

amino acid and derivatives; macrocycles; oxazoles; Combinatorial Chemistry;

D O I：

10.1016/S0040-4039(98)01170-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new class of analogs of natural products useful for supramolecular and combinatorial chemistry is presented. Starting from the structure of natural dolastatins, we have designed and synthesized a series of amino acid-based unnatural rigid platforms having multiple functional groups pointing in the same direction. The stereochemistry of the final product is entirely determined by the chirality of the constituent amino acids. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：5709 / 5712

页数：4

共 50 条

[31] Combinatorial chemistry in cancer research [J].

A. Messeguer ;

N. Cortés .

Clinical and Translational Oncology, 2007, 9 :83-92

[32] Future pathways for combinatorial chemistry [J].

David Brown .

Molecular Diversity, 1997, 2 :217-222

[33] The many faces of combinatorial chemistry [J].

Borman, Stu .

Chemical and Engineering News, 2003, 81 (43) :45-56

[34] RADIOFREQUENCY ENCODED COMBINATORIAL CHEMISTRY [J].

NICOLAOU, KC ;

XIAO, XY ;

PARANDOOSH, Z ;

SENYEI, A ;

NOVA, MP .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1995, 34 (20) :2289-2291

[35] Multicomponent reactions and combinatorial chemistry [J].

M. A. Mironov .

Russian Journal of General Chemistry, 2010, 80 :2628-2646

[36] Combinatorial chemistry in cancer research [J].

Messeguer, A. ;

Cortes, N. .

CLINICAL & TRANSLATIONAL ONCOLOGY, 2007, 9 (02) :83-92

[37] Applications of combinatorial chemistry in the AgroSciences [J].

Scherkenbeck, E ;

Lindell, S .

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, 2005, 8 (07) :563-576

[38] Diketopiperazines in peptide and combinatorial chemistry [J].

Fischer, PM .

JOURNAL OF PEPTIDE SCIENCE, 2003, 9 (01) :9-35

[39] Mass spectrometry in combinatorial chemistry [J].

Enjalbal, C ;

Martinez, J ;

Aubagnac, JL .

MASS SPECTROMETRY REVIEWS, 2000, 19 (03) :139-161

[40] Combinatorial chemistry in organic synthesis [J].

Takahashi, T ;

Doi, T .

JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 2002, 60 (05) :426-433

← 1 2 3 4 5 →