The Role of Ghrelin and Ghrelin Signaling in Aging

被引：33

作者：

Amitani, Marie ^{[1
,2
]}

Amitani, Haruka ^{[2
]}

Cheng, Kai-Chun ^{[2
]}

Kairupan, Timothy Sean ^{[2
]}

Sameshima, Nanami ^{[2
]}

Shimoshikiryo, Ippei ^{[3
]}

Mizuma, Kimiko ^{[1
]}

Rokot, Natasya Trivena ^{[2
]}

Nerome, Yasuhito ^{[1
]}

Owaki, Tetsuhiro ^{[1
]}

Asakawa, Akihiro ^{[2
]}

Inui, Akio ^{[2
]}

机构：

[1] Kagoshima Univ, Grad Sch Med & Dent Sci, Educ Ctr Doctors Remote Islands & Rural Areas, Kagoshima 8908544, Japan

[2] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Psychosomat Internal Med, Kagoshima 8908544, Japan

[3] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Int Isl & Community Med, Kagoshima 8908544, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 07期

关键词：

ghrelin; calorie restriction; longevity; ghrelin resistance; ghrelin agonist; GROWTH-HORMONE SECRETAGOGUE; LIFE-SPAN EXTENSION; CALORIC RESTRICTION; CAENORHABDITIS-ELEGANS; DIETARY RESTRICTION; NEUROPEPTIDE-Y; MALE-MICE; PLASMA GHRELIN; MESSENGER-RNA; OLDER-ADULTS;

D O I：

10.3390/ijms18071511

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

With our aging society, more people hope for a long and healthy life. In recent years, researchers have focused on healthy longevity factors. In particular, calorie restriction delays aging, reduces mortality, and extends life. Ghrelin, which is secreted during fasting, is well known as an orexigenic peptide. Because ghrelin is increased by caloric restriction, ghrelin may play an important role in the mechanism of longevity mediated by calorie restriction. In this review, we will discuss the role of orexigenic peptides with a particular focus on ghrelin. We conclude that the ghrelin-growth hormone secretagogue-R signaling pathway may play an important role in the anti-aging mechanism.

引用

页数：18

共 50 条

[1] Ghrelin Signaling in Immunometabolism and Inflamm-Aging
Fang, Chuo
Xu, Hang
Guo, Shaodong
Mertens-Talcott, Susanne U.
Sun, Yuxiang
NEURAL REGULATION OF METABOLISM, 2018, 1090 : 165 - 182
[2] Ghrelin/ghrelin receptors
Kaiya, Hiroyuki
Kangawa, Kenji
Miyazato, Mikiya
JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2014, 52 (03) : T87 - T100
[3] Ghrelin and its receptor: The role of the ghrelin signaling system in regulating cardiac function
Soeki, Takeshi
REGULATORY PEPTIDES, 2014, 192 : 57 - 58
[4] The role of ghrelin in addiction: a review
Panagopoulos, Vassilis N.
Ralevski, Elizabeth
PSYCHOPHARMACOLOGY, 2014, 231 (14) : 2725 - 2740
[5] Ghrelin, des-acyl ghrelin and nesfatin-1 in gastric X/A-like cells: Role as regulators of food intake and body weight
Stengel, Andreas
Goebel, Miriam
Wang, Lixin
Tache, Yvette
PEPTIDES, 2010, 31 (02) : 357 - 369
[6] The role of ghrelin in the organism
Polinska, Beata
Matowicka-Karna, Joanna
Kemona, Halina
POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ, 2011, 65 : 1 - 7
[7] GHRELIN ROLE IN HYPOTHALAMUS-PITUITARY-OVARIAN AXIS
Rak-Mardyla, A.
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2013, 64 (06): : 695 - 704
[8] Intranasal Delivery of a Ghrelin Mimetic Engages the Brain Ghrelin Signaling System in Mice
Poelman, Renee
Le May, Marie, V
Schele, Erik
Stoltenborg, Iris
Dickson, Suzanne L.
ENDOCRINOLOGY, 2025, 166 (03)
[9] The octanoylated energy regulating hormone ghrelin: An expanded view of ghrelin's biological interactions and avenues for controlling ghrelin signaling
Cleverdon, Elizabeth R.
McGovern-Gooch, Kayleigh R.
Hougland, James L.
MOLECULAR MEMBRANE BIOLOGY, 2016, 33 (6-8) : 111 - 124
[10] Ghrelin in Central Neurons
Ferrini, F.
Salio, C.
Lossi, L.
Merighi, A.
CURRENT NEUROPHARMACOLOGY, 2009, 7 (01) : 37 - 49

← 1 2 3 4 5 →