The Role of Ghrelin and Ghrelin Signaling in Aging

被引：34

作者：

Amitani, Marie ^{[1
,2
]}

Amitani, Haruka ^{[2
]}

Cheng, Kai-Chun ^{[2
]}

Kairupan, Timothy Sean ^{[2
]}

Sameshima, Nanami ^{[2
]}

Shimoshikiryo, Ippei ^{[3
]}

Mizuma, Kimiko ^{[1
]}

Rokot, Natasya Trivena ^{[2
]}

Nerome, Yasuhito ^{[1
]}

Owaki, Tetsuhiro ^{[1
]}

Asakawa, Akihiro ^{[2
]}

Inui, Akio ^{[2
]}

机构：

[1] Kagoshima Univ, Grad Sch Med & Dent Sci, Educ Ctr Doctors Remote Islands & Rural Areas, Kagoshima 8908544, Japan

[2] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Psychosomat Internal Med, Kagoshima 8908544, Japan

[3] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Int Isl & Community Med, Kagoshima 8908544, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 07期

关键词：

ghrelin; calorie restriction; longevity; ghrelin resistance; ghrelin agonist; GROWTH-HORMONE SECRETAGOGUE; LIFE-SPAN EXTENSION; CALORIC RESTRICTION; CAENORHABDITIS-ELEGANS; DIETARY RESTRICTION; NEUROPEPTIDE-Y; MALE-MICE; PLASMA GHRELIN; MESSENGER-RNA; OLDER-ADULTS;

D O I：

10.3390/ijms18071511

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

With our aging society, more people hope for a long and healthy life. In recent years, researchers have focused on healthy longevity factors. In particular, calorie restriction delays aging, reduces mortality, and extends life. Ghrelin, which is secreted during fasting, is well known as an orexigenic peptide. Because ghrelin is increased by caloric restriction, ghrelin may play an important role in the mechanism of longevity mediated by calorie restriction. In this review, we will discuss the role of orexigenic peptides with a particular focus on ghrelin. We conclude that the ghrelin-growth hormone secretagogue-R signaling pathway may play an important role in the anti-aging mechanism.

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页数：18

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