Isolation of a novel fish thymidylate kinase gene, upregulated in Atlantic salmon (Salmo salar L.) following infection with the monogenean parasite Gyrodactylus salaris

被引：13
作者：
Collins, Catherine A.
Olstad, Kjetil
Sterud, Erik
Jones, Catherine S.
Noble, Leslie R.
Mo, Tor Atle
Cunningham, Carey O.
机构：
[1] FRS Marine Lab Mol Genet, Aberdeen AB11 9BD, Scotland
[2] Univ Oslo, Zool Museum, N-0318 Oslo, Norway
[3] Natl Vet Inst, N-0033 Oslo, Norway
[4] Univ Aberdeen, Sch Biol Sci, Aberdeen AB24 2TZ, Scotland
来源：
FISH & SHELLFISH IMMUNOLOGY | 2007年 / 23卷 / 04期
关键词：
salmon; Gyrodactylus; infection; differential display; gene expression; immune response; thymidylate kinase; RT-PCR;
D O I：
10.1016/j.fsi.2007.03.001
中图分类号：
S9 [水产、渔业];
学科分类号：
0908 ;
摘要：
Analysis of differential gene expression in salmon (Salmo salar) blood following infection with the monogenean parasite Gyrodactylus salaris, resulted in the isolation of a thymidylate kinase gene not previously described from fish and which showed similarity to an LPS-inducible thymidylate kinase gene isolated from mouse macrophages. This salmon TYKi-like gene may play a role in an innate generalised response to pathogen infection as it was upregulated in salmon following infection with the parasite, and also in response to injection with the immunostimulants LPS and Poly I:C, used to emulate bacterial and viral infections, respectively. The possible role of this gene in the biosynthesis of mitochondrial DNA in activated macrophages, in response to G. salaris infection is discussed. (c) 2007 Published by Elsevier Ltd.
引用
收藏
页码：793 / 807
页数：15
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