Symptomatic Radiation Pneumonitis After Accelerated Partial Breast Irradiation Using Three-dimensional Conformal Radiotherapy

被引:0
|
作者
Shikama, Naoto [1 ]
Kumazaki, Yu [1 ]
Miyazawa, Kazunari [1 ]
Miyaura, Kazunori [1 ]
Kato, Shingo [1 ]
Nakamura, Naoki [4 ]
Kawamori, Jiro [5 ]
Shimizuguchi, Takuya [6 ]
Saito, Naoko [2 ]
Saeki, Toshiaki [3 ]
机构
[1] Saitama Med Univ, Int Med Ctr, Dept Radiat Oncol, 1397-1 Yamane, Hidaka City, Saitama 3501298, Japan
[2] Saitama Med Univ, Int Med Ctr, Dept Radiol, 1397-1 Yamane, Hidaka City, Saitama 3501298, Japan
[3] Saitama Med Univ, Int Med Ctr, Dept Breast Oncol Serv, 1397-1 Yamane, Hidaka City, Saitama 3501298, Japan
[4] Natl Canc Ctr East, Dept Radiat Oncol, Chiba, Japan
[5] St Lukes Int Hosp, Dept Radiat Oncol, Tokyo, Japan
[6] Komagome Hosp, Tokyo Metropolitan Canc & Infect Dis Ctr, Div Radiat Oncol, Tokyo, Japan
关键词
Partial breast irradiation; breast cancer; adverse event; three-dimensional conformal radiotherapy; symptomatic pneumonitis; RISK;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Aim: To examine the relationship between symptomatic radiation pneumonitis and lung dose-volume parameters for patients receiving accelerated partial breast irradiation (APBI) using three dimensional-conformal radiotherapy (3D-CRT). Patients and Methods: The prescribed radiation dose was 30 Gy in 5 fractions over 10 days. Toxicity was graded according to the Common Terminology Criteria for Adverse Events (version 4.0). Results: Fifty-five patients were enrolled from August 2010 to October 2013 and the median follow-up time was 30 months (range=18-46 months). Three patients (5%) developed grade 2 symptomatic radiation pneumonitis after 3D-CRT APBI. Among 16 patients with ILV10Gy (% ipsilateral lung receiving >= 10 Gy) of 10% or higher, three patients (19%) developed symptomatic radiation pneumonitis. This trend was not observed in any of the patients with ILV10Gy less than 10% (p=0.005). Conclusion: High ILV10Gy might be associated with symptomatic radiation pneumonitis after 3D-CRT APBI.
引用
收藏
页码:2475 / 2479
页数:5
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