Microglia activation is related to substantia nigra echogenicity

被引：81

作者：

Berg, D. ^{[1
,2
]}

Godau, J. ^{[1
,2
]}

Riederer, P. ^{[3
]}

Gerlach, M. ^{[4
]}

Arzberger, T. ^{[5
]}

机构：

[1] Univ Tubingen, Dept Neurodegenerat, Hertie Inst Clin Brain Res, D-72076 Tubingen, Germany

[2] Univ Tubingen, German Ctr Neurodegenerat Dis DZNE, D-72076 Tubingen, Germany

[3] Univ Wurzburg, Dept Psychiat Psychosomat & Psychotherapy, NPF Ctr Excellence Labs, Wurzburg, Germany

[4] Univ Wurzburg, Dept Child & Adolescent Psychiat, Wurzburg, Germany

[5] Univ Munich, Ctr Neuropathol & Prion Res, Munich, Germany

来源：

JOURNAL OF NEURAL TRANSMISSION | 2010年 / 117卷 / 11期

关键词：

Microglia; Ultrasound; Substantia nigra; Parkinson's disease; PARKINSONS-DISEASE; TRANSCRANIAL SONOGRAPHY; IRON; NEUROMELANIN; FERRITIN; BRAIN; ULTRASOUND; PATHWAYS; MARKER;

D O I：

10.1007/s00702-010-0504-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Hyperechogenicity of the substantia nigra (SN) is a sensitive marker for Parkinson's disease (PD). Previously, a relation between SN echogenicity and iron as well as neuromelanin content could be described in 60 human brains. In the present study on a subset of 33 brains, SN echogenicity was found to be correlated with microglia activation (rho = 0.46, p = 0.008) after correction for iron and neuromelanin content. These findings strengthen the hypothesis of a close pathophysiological connection between SN hyperechogenicity and PD pathology.

引用

页码：1287 / 1292

页数：6

共 18 条

[1] IRON MELANIN INTERACTION AND LIPID-PEROXIDATION - IMPLICATIONS FOR PARKINSONS-DISEASE [J].

BENSHACHAR, D ;

RIEDERER, P ;

YOUDIM, MBH .

JOURNAL OF NEUROCHEMISTRY, 1991, 57 (05) :1609-1614

[2] Echogenicity of the substantia nigra -: Association with increased iron content and marker for susceptibility to nigrostriatal injury [J].

Berg, D ;

Roggendorf, W ;

Schröder, U ;

Klein, R ;

Tatschner, T ;

Benz, P ;

Tucha, O ;

Preier, M ;

Lange, KW ;

Reiners, K ;

Gerlach, M ;

Becker, G .

ARCHIVES OF NEUROLOGY, 2002, 59 (06) :999-1005

[3] Brain iron pathways and their relevance to Parkinson's disease [J].

Berg, D ;

Gerlach, M ;

Youdim, MBH ;

Double, KL ;

Zecca, L ;

Riederer, P ;

Becker, G .

JOURNAL OF NEUROCHEMISTRY, 2001, 79 (02) :225-236

[4] Iron accumulation in the substantia nigra in rats visualized by ultrasound [J].

Berg, D ;

Grote, C ;

Rausch, WD ;

Mäurer, M .

ULTRASOUND IN MEDICINE AND BIOLOGY, 1999, 25 (06) :901-904

[5] Transcranial sonography in movement disorders [J].

Berg, Daniela ;

Godau, Jana ;

Walter, Uwe .

LANCET NEUROLOGY, 2008, 7 (11) :1044-1055

[6] Staging of brain pathology related to sporadic Parkinson's disease [J].

Braak, H ;

Del Tredici, K ;

Rüb, U ;

de Vos, RAI ;

Steur, ENHJ ;

Braak, E .

NEUROBIOLOGY OF AGING, 2003, 24 (02) :197-211

[7] ISOFORMS OF FERRITIN HAVE A SPECIFIC CELLULAR-DISTRIBUTION IN THE BRAIN [J].

CONNOR, JR ;

BOESHORE, KL ;

BENKOVIC, SA ;

MENZIES, SL .

JOURNAL OF NEUROSCIENCE RESEARCH, 1994, 37 (04) :461-465

[8] Evidence for specific phases in the development of human neuromelanin [J].

Fedorow, H ;

Halliday, GM ;

Rickert, CH ;

Gerlach, A ;

Riederer, P ;

Double, KL .

NEUROBIOLOGY OF AGING, 2006, 27 (03) :506-512

[9] The specificity and sensitivity of transcranial ultrasound in the differential diagnosis of Parkinson's disease: a prospective blinded study [J].

Gaenslen, Alexandra ;

Unmuth, Barbara ;

Godau, Jana ;

Liepelt, Ingo ;

Di Santo, Adriona ;

Schweitzer, Katherine Johanna ;

Gasser, Thomas ;

Machulla, Hans-Juergen ;

Reimold, Matthias ;

Marek, Kenneth ;

Berg, Daniela .

LANCET NEUROLOGY, 2008, 7 (05) :417-424

[10] FERRITIN IMMUNOHISTOCHEMISTRY AS A MARKER FOR MICROGLIA [J].

KANEKO, Y ;

KITAMOTO, T ;

TATEISHI, J ;

YAMAGUCHI, K .

ACTA NEUROPATHOLOGICA, 1989, 79 (02) :129-136

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