Synthesis and general properties of silated-hydroxypropyl methylcellulose in prospect of biomedical use

被引：104

作者：

Bourges, X

Weiss, P

Daculsi, G

Legeay, G

机构：

[1] Fac Chirurg Dent, INSERM E99 03, Lab Tissus Calcifies, F-44042 Nantes, France

[2] Ctr Transfert Technol Mans, F-72000 Le Mans, France

来源：

ADVANCES IN COLLOID AND INTERFACE SCIENCE | 2002年 / 99卷 / 03期

关键词：

silane; silanol; synthesis; hydroxypropyl methylcellulose; condensation;

D O I：

10.1016/S0001-8686(02)00035-0

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Synthesis of grafting silane on a hydro, soluble cellulose ether (HPMC) was described. In alkaline medium, this derivate is under gel form. With a decrease of the pH, a self-hardening occurs due to the silanol condensation. For potential biomedical use, we described the silated-HPMC synthesis, the gel behavior after steam sterilization and the parameters of the silanol condensation i.e. pH, silane percentage and temperature. Minimum kinetic of the condensation was observed for pH between 5.5 and 6.5. So temperature catalyzed the reaction and the self-hardening speed was increased by silane percentage. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：215 / 228

页数：14

共 33 条

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