New anticancer zinc(II) complexes comprising thiosemicarbazones of saturated ring: structure, DNA/protein binding, DNA cleavage, topoisomerase-1 inhibition and anti-proliferation studies

被引：7
作者：
Rajamuthy, Vikneswaran [1 ]
Eltayeb, Naser Eltaher [2 ]
Subramaniam, Ramesh [1 ]
Rosiyah, Yahya [3 ]
机构：
[1] Univ Malaya, Fac Sci, Ctr Ion, Kuala Lumpur 50603, Malaysia
[2] King Abdulaziz Univ, Sci & Arts Coll Rabigh, Dept Chem, Rabigh, Saudi Arabia
[3] Univ Malaya, Fac Sci, Dept Chem, Kuala Lumpur 50603, Malaysia
来源：
APPLIED ORGANOMETALLIC CHEMISTRY | 2016年 / 30卷 / 06期
关键词：
alicyclic thiosemicarbazone; zinc(II) complexes; DNA binding; DNA cleavage; topoisomerase inhibition; antitumor; METAL-COMPLEXES; SPECIFICITY; DERIVATIVES; AGENTS;
D O I：
10.1002/aoc.3458
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The reaction of the thiosemicarbazones (CH2)(4)C=NN(H)C(=S)NHR (R = H, Me) with zinc(II) acetate in methanolic solution proceeds readily under mild conditions to form stable mononuclear complexes Zn[(CH2)(4)C=NN=C(S)NHR](2). DNA interaction studies show that the zinc(II) complexes bind to DNA via groove mode and exhibit efficient DNA cleavage activity in the presence of hydrogen peroxide. Also, the complexes display a binding affinity to bovine serum albumin protein with K-BSA values of ca 10(5) M-1. Topoisomerase catalytic inhibition studies suggest that both complexes are efficient topoisomerase-I impeders. Furthermore, the anti-proliferative effects of the two complexes on five human tumor cell lines (Caki-2, MCF-7, CaSki, NCI-H322M and Co-115) indicate that both complexes have the potential to act as effective anticancer drugs. Copyright (C) 2016 John Wiley & Sons, Ltd.
引用
收藏
页码：481 / 487
页数：7
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