Neutrophil dysregulation during sepsis: an overview and update

被引：241

作者：

Shen, Xiao-Fei ^{[1
]}

Cao, Ke ^{[2
]}

Jiang, Jin-Peng ^{[3
]}

Guan, Wen-Xian ^{[1
]}

Du, Jun-Feng ^{[4
]}

机构：

[1] Nanjing Univ, Affiliated Drum Tower Hosp, Dept Gen Surg, Sch Med, Nanjing, Jiangsu, Peoples R China

[2] Nanjing Univ, Affiliated Drum Tower Hosp, Dept Intens Care Unit, Sch Med, Nanjing, Jiangsu, Peoples R China

[3] PLA Army Gen Hosp, Dept Rehabil Med, Beijing, Peoples R China

[4] PLA Army Gen Hosp, Dept Gen Surg, Beijing, Peoples R China

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2017年 / 21卷 / 09期

基金：

中国国家自然科学基金;

关键词：

sepsis; neutrophil migration; neutrophil antimicrobial activity; neutrophil extracellular traps; signal pathway; INTENSIVE-CARE UNITS; INTERNATIONAL CONSENSUS DEFINITIONS; INDUCIBLE NITRIC-OXIDE; EXTRACELLULAR TRAPS; POLYMICROBIAL SEPSIS; CD64; EXPRESSION; CELL-DEATH; INDUCED IMMUNOSUPPRESSION; CIRCULATING NEUTROPHILS; PROGNOSTIC MARKER;

D O I：

10.1111/jcmm.13112

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sepsis remains a leading cause of death worldwide, despite advances in critical care, and understanding of the pathophysiology and treatment strategies. No specific therapy or drugs are available for sepsis. Neutrophils play a critical role in controlling infection under normal conditions, and it is suggested that their migration and antimicrobial activity are impaired during sepsis which contribute to the dysregulation of immune responses. Recent studies further demonstrated that interruption or reversal of the impaired migration and antimicrobial function of neutrophils improves the outcome of sepsis in animal models. In this review, we provide an overview of the associated mediators and signal pathways involved which govern the survival, migration and antimicrobial function of neutrophils in sepsis, and discuss the potential of neutrophils as a target to specifically diagnose and/or predict the outcome of sepsis.

引用

页码：1687 / 1697

页数：11

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