Gadoxetate disodium-related event during image acquisition: a prospective multi-institutional study for better MR practice

被引：11

作者：

Kromrey, Marie-Luise ^{[1
,2
]}

Hori, Masatoshi ^{[3
]}

Goshima, Satoshi ^{[4
]}

Kozaka, Kazuto ^{[5
]}

Hyodo, Tomoko ^{[6
]}

Nakamura, Yuko ^{[7
]}

Nishie, Akihiro ^{[8
]}

Tamada, Tsutomu ^{[9
]}

Shimizu, Tatsuya ^{[1
]}

Kanki, Akihiko ^{[9
]}

Motosugi, Utaroh ^{[1
]}

机构：

[1] Univ Yamanashi, Dept Radiol, Chuo Ku, 1110 Shimokato, Kofu, Yamanashi 4093898, Japan

[2] Univ Med Greifswald, Dept Diagnost Radiol & Neuroradiol, Greifswald, Germany

[3] Osaka Univ, Dept Diagnost & Intervent Radiol, Grad Sch Med, Suita, Osaka, Japan

[4] Hamamatsu Univ, Dept Diagnost Radiol & Nucl Med, Sch Med, Hamamatsu, Shizuoka, Japan

[5] Kanazawa Univ, Dept Radiol, Kanazawa, Ishikawa, Japan

[6] Kindai Univ, Dept Radiol, Fac Med, Osaka, Japan

[7] Hiroshima Univ, Diagnost Radiol, Hiroshima, Japan

[8] Kyushu Univ, Grad Sch Med Sci, Dept Clin Radiol, Fukuoka, Fukuoka, Japan

[9] Kawasaki Med Sch, Dept Radiol, Kurashiki, Okayama, Japan

来源：

EUROPEAN RADIOLOGY | 2020年 / 30卷 / 01期

关键词：

Dyspnea; Breath-holding; Magnetic resonance imaging; Gadoxetate disodium; RESPIRATORY MOTION ARTIFACTS; HEPATIC ARTERIAL PHASE; TRANSIENT SEVERE MOTION; ENHANCED MRI; REDUCING ARTIFACTS; PRIOR EPISODE; ACID; REDUCTION;

D O I：

10.1007/s00330-019-06358-7

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose To acknowledge the facts of gadoxetate disodium-related events in Japan and to achieve better MR practice by analyzing large cohort data with various MR parameters. Materials and methods This prospective multi-institutional study included 1993 patients (1201 men, mean age 66.4 +/- 12.8 years), who received dynamic MRI with gadoxetate disodium (gadoxetate group, n = 1646) or extracellular gadolinium-based contrast agents (other-GBCAs group, n = 347) between January and November 2016. Recorded data covered adverse reactions including dyspnea, breath-hold failure during acquisition, respiratory artifacts rated with a four-point scale, and MR parameters. We compared data between the two groups in whole cohort and age-, gender-, and institution-matched subcohort using chi(2) test (n = 640). Logistic regression model was used to reveal independent associates of substantial artifacts in arterial phase imaging. Results Transient dyspnea rarely occurred in gadoxetate or other-GBCAs group (both < 1%). Gadoxetate group (vs other-GBCAs group) showed higher rates of breath-hold failure (whole cohort, 18.2% vs 7.7%, p < 0.001; subcohort, 17.6% vs 6.3%, p < 0.001) and substantial artifacts in arterial phase (7.2% vs 2.2%, p = 0.001; 7.4% vs 1.7%, p = 0.001). With single arterial phase protocol, substantial artifacts under gadoxetate were independently associated with age (odds ratio [OR] = 1.04, p < 0.001), hearing difficulty (OR = 2.92, p = 0.008), breath-hold practice required (OR = 1.61, p = 0.039), and short acquisition time (OR = 0.43, p = 0.005). Multiple arterial phase acquisition did not reduce the incident rate of substantial artifacts. Conclusion Gadoxetate disodium was associated with breath-hold failure and substantial artifacts in arterial phase imaging, but not with dyspnea in Japan. Shorter acquisition time should be used to sustain image quality in gadoxetate disodium-enhanced arterial phase imaging.

引用

页码：281 / 290

页数：10

共 34 条

[1] Respiratory Motion Artifact Affecting Hepatic Arterial Phase MR Imaging with Gadoxetate Disodium Is More Common in Patients with a Prior Episode of Arterial Phase Motion Associated with Gadoxetate Disodium [J].