An efficient route towards the synthesis of monosubstituted N-aryl amidines from 4,5-dihydro-1,2,4-oxadiazoles

被引：8

作者：

Chavan, Neelam L. ^{[1
]}

Naik, Nilesh H. ^{[1
]}

Nayak, Sandip K. ^{[2
]}

Kusurkar, Radhika S. ^{[1
]}

机构：

[1] Univ Pune, Dept Chem, Pune 411007, Maharashtra, India

[2] Bhabha Atom Res Ctr, Div Bioorgan, Bombay 400085, Maharashtra, India

来源：

ARKIVOC | 2010年

关键词：

N-aryl amidines; 4,5-dihydro-1,2,4-oxadiazoles; hydrogenolysis; Nitrile oxides; 1,3-dipolar cycloaddition reaction; ONE-STEP SYNTHESIS; 1,3-DIPOLAR CYCLOADDITION; NITRILES; AMINES;

D O I：

10.3998/ark.5550190.0011.220

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4,5-Dihydro-1,2,4-oxadiazoles were prepared using 1,3-dipolar cycloaddition of imines with nitrile oxides. Further reductive N-O bond cleavage furnished monosubstituted N-aryl amidines in good yield. Thus an efficient route for the synthesis of monosubstituted N-aryl amidines has been developed.

引用

页码：248 / 255

页数：8

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