Longitudinal Changes in Anger, Anxiety, and Fatigue Are Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease

被引：14
作者：
Babulal, Ganesh M. [1 ,2 ,3 ,4 ]
Chen, Ling [5 ]
Doherty, Jason M. [1 ]
Murphy, Samantha A. [1 ]
Johnson, Ann M. [6 ]
Roe, Catherine M. [1 ]
机构：
[1] Washington Univ, Dept Neurol, St Louis, MO 63110 USA
[2] Washington Univ, Inst Publ Hlth, St Louis, MO 63110 USA
[3] Univ Johannesburg, Fac Humanities, Dept Psychol, Johannesburg, South Africa
[4] George Washington Univ, Sch Med & Hlth Sci, Dept Clin Res & Leadership, Washington, DC 20052 USA
[5] Washington Univ, Div Biostat, St Louis, MO 63110 USA
[6] Washington Univ, Ctr Clin Studies, St Louis, MO 63110 USA
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2022年 / 87卷 / 01期
关键词：
Alzheimer's disease; anger; anxiety; biomarkers; cerebrospinal fluid; older adults; MILD BEHAVIORAL IMPAIRMENT; COGNITIVE IMPAIRMENT; DEPRESSIVE SYMPTOMS; OLDER-ADULTS; DEMENTIA; TAU; NEURODEGENERATION; PREVALENCE; PROFILE; DECLINE;
D O I：
10.3233/JAD-215708
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Alzheimer's disease (AD) studies in cognitively normal (CN) older adults age >= 65 suggest depression is associated with molecular biomarkers (imaging and cerebrospinal fluid [CSF]). This study used linear mixed models (covariance pattern model) to assess whether baseline CSF biomarkers (A beta(42)/A beta(40), t-Tau/A beta(42) , p-Tau/A beta(42)) predicted changes in non-depressed mood states in CN older adults (N= 248), with an average of three follow-up years. Participants with higher levels of CSF biomarkers developed more anger, anxiety, and fatigue over time compared to those with more normal levels. Non-depressed mood states in preclinical AD may be a prodrome for neuropsychiatric symptoms in symptomatic AD.
引用
收藏
页码：141 / 148
页数：8
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